Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Metallomics. 2012 Aug;4(9):866-80. doi: 10.1039/c2mt20082a.
Siderophores are low-molecular-weight iron chelators that are produced and exported by bacteria, fungi and plants during periods of nutrient deprivation. The structures, biosynthetic logic, and coordination chemistry of these molecules have fascinated chemists for decades. Studies of such fundamental phenomena guide the use of siderophores and siderophore conjugates in a variety of medicinal applications that include iron-chelation therapies and drug delivery. Sensing applications constitute another important facet of siderophore-based technologies. The high affinities of siderophores for both ferric ions and siderophore receptors, proteins expressed on the cell surface that are required for ferric siderophore import, indicate that these small molecules may be employed for the selective capture of metal ions, proteins, and live bacteria. This minireview summaries progress in methods that utilize native bacterial and fungal siderophore scaffolds for the detection of Fe(III) or microbial pathogens.
铁载体是一种低分子量的铁螯合剂，在营养缺乏时期，细菌、真菌和植物会产生并分泌这种物质。几十年来，这些分子的结构、生物合成逻辑和配位化学一直令化学家着迷。对这些基本现象的研究指导了铁载体及其铁载体缀合物在各种医学应用中的使用，包括铁螯合疗法和药物输送。传感应用是基于铁载体技术的另一个重要方面。铁载体对三价铁离子和铁载体受体（细胞表面表达的用于摄取三价铁载体的蛋白质）的高亲和力表明，这些小分子可用于选择性捕获金属离子、蛋白质和活细菌。这篇综述总结了利用天然细菌和真菌铁载体支架检测 Fe(III)或微生物病原体的方法进展。
