IgG4 相关眼病中眶下神经增大的病理发现。
Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease.
机构信息
Department of Ophthalmology, Mitoyo General Hospital, 708 Himehama, Toyohama-cho, Kanonji, Kagawa 769-1695, Japan.
出版信息
Jpn J Ophthalmol. 2012 Sep;56(5):511-4. doi: 10.1007/s10384-012-0170-3. Epub 2012 Jul 27.
PURPOSE
We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings.
CASE
An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed IgG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well.
CONCLUSION
IONE in IgG4-related ophthalmic disease is due to IgG4-related disease involving the epineurium.
目的
我们报告一例与 IgG4 相关眼病相关的双侧眶下神经肿大（IONE）病例，并描述其相关的组织病理学发现。
病例
一名 59 岁健康男性患者表现为双侧眼球突出和右眼视力障碍。眼眶磁共振成像显示双侧 IONE 和右侧眶内软组织肿块。在左侧眶下管进行了切除活检。组织病理学评估显示 IgG4 相关疾病累及眶下神经的神经外膜。患者接受了全身类固醇治疗，反应良好。
结论
IgG4 相关眼病中的 IONE 是由于 IgG4 相关疾病累及神经外膜所致。
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