玻璃体内切除术后丝裂霉素 C 小梁切除术失败的预后危险因素。
Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy.
机构信息
Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan.
出版信息
Jpn J Ophthalmol. 2012 Sep;56(5):464-9. doi: 10.1007/s10384-012-0171-2. Epub 2012 Aug 2.
PURPOSE
To evaluate the prognostic risk factors for failure of trabeculectomy with mitomycin C (MMC) in vitrectomized eyes.
METHODS
Retrospective cohort study. We reviewed the medical records of 116 patients (116 eyes) treated at Kumamoto University Hospital. The primary endpoints were persistent intraocular pressure of >21 mmHg, deterioration of visual acuity to no light perception, or additional glaucoma procedures. Multivariable analysis was performed with the Cox proportional hazards model.
RESULTS
The mean follow-up period was 36.5 months (range, 0.5-134.1 months). The probability of success 1 year after trabeculectomy was 55.1 %, 2 years after was 45.3 %, and 3 years after was 43.1 %. The multivariable model showed that higher preoperative intraocular pressure (IOP) [relative risk (RR), 1.05/mmHg; P = 0.0077] and neovascular glaucoma (NVG) (RR, 1.88; P = 0.049) were prognostic factors for surgical failure.
CONCLUSIONS
The prognostic factors for surgical failure of trabeculectomy with MMC in vitrectomized eyes are a higher preoperative IOP and NVG.
目的
评估玻璃体内切除术后丝裂霉素 C（MMC）小梁切除术失败的预后危险因素。
方法
回顾性队列研究。我们回顾了在熊本大学医院接受治疗的 116 名患者（116 只眼）的病历。主要终点是眼内压持续>21mmHg、视力恶化至无光感或需要进行额外的青光眼手术。采用 Cox 比例风险模型进行多变量分析。
结果
平均随访时间为 36.5 个月（范围：0.5-134.1 个月）。小梁切除术 1 年后的成功率为 55.1%，2 年后为 45.3%，3 年后为 43.1%。多变量模型显示，较高的术前眼内压（RR，1.05/mmHg；P=0.0077）和新生血管性青光眼（NVG）（RR，1.88；P=0.049）是手术失败的预后因素。
结论
玻璃体内切除术后 MMC 小梁切除术失败的预后因素是较高的术前眼内压和 NVG。
Zotero 插件