Department of Neurology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.
IEEE Trans Neural Syst Rehabil Eng. 2013 May;21(3):346-53. doi: 10.1109/TNSRE.2012.2206829. Epub 2012 Jul 27.
In modeling the effect of transcranial direct current stimulation, the representation of the skull is an important factor. In a spherical model, we compared a realistic skull modeling approach, in which the skull consisted of three isotropic layers, to anisotropic and isotropic single-layer approximations. We simulated direct current stimulation for a range of conductivity values and investigated differences in the resulting current densities. Our results demonstrate that both approximation methods perform well, provided that the optimal conductivity values are used. We found that for both the anisotropic and the isotropic approximations the optimal conductivity values are largely dictated by the equivalent radial conductivity of the three-layered skull.
在模拟经颅直流电刺激的效果时，颅骨的表示是一个重要因素。在球模型中，我们比较了一种现实的颅骨建模方法，其中颅骨由三个各向同性层组成，与各向异性和各向同性单层近似方法进行比较。我们模拟了一系列电导率值的直流电刺激，并研究了由此产生的电流密度的差异。我们的结果表明，只要使用最佳电导率值，这两种近似方法都能很好地工作。我们发现，对于各向异性和各向同性近似方法，最佳电导率值在很大程度上取决于三层颅骨的等效径向电导率。
