D1 受体对前额叶皮层第 5 层锥体神经元亚群动作电位发放的调制。
D1 receptor modulation of action potential firing in a subpopulation of layer 5 pyramidal neurons in the prefrontal cortex.
机构信息
Center for Neural Science, New York University, New York, New York 10003, USA.
出版信息
J Neurosci. 2012 Aug 1;32(31):10516-21. doi: 10.1523/JNEUROSCI.1367-12.2012.
Abstract
Dopamine modulation in the prefrontal cortex is important for cognitive processing and disrupted in diverse neuropsychiatric diseases. Activation of D1 receptors is thought to enable working memory by enhancing the firing properties of pyramidal neurons. However, these receptors are only sparsely expressed in the prefrontal cortex, and how they impact individual neurons remains unknown. Here we study D1 receptor modulation of layer 5 pyramidal neurons in acute slices of the mouse prefrontal cortex. Using whole-cell recordings and two-photon microscopy, we show that neurons expressing D1 receptors have unique morphological and physiological properties. We then demonstrate that activation of these receptors selectively enhances the firing of these neurons by signaling via the protein kinase A pathway. This finding of robust D1 receptor modulation in only a subpopulation of neurons has important implications for cognitive function and disease.
摘要
前额叶皮层中的多巴胺调节对于认知处理很重要，并且在多种神经精神疾病中受到干扰。D1 受体的激活被认为可以通过增强锥体神经元的放电特性来实现工作记忆。然而，这些受体在前额叶皮层中仅稀疏表达，并且它们如何影响单个神经元仍然未知。在这里，我们研究了急性小鼠前额叶皮层切片中 D1 受体对第 5 层锥体神经元的调节。使用全细胞膜片钳记录和双光子显微镜，我们表明表达 D1 受体的神经元具有独特的形态和生理特性。然后，我们证明通过蛋白激酶 A 途径的信号转导，这些受体的激活选择性地增强了这些神经元的放电。这种仅在神经元的亚群中发现的强大 D1 受体调节对认知功能和疾病具有重要意义。
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