Antimicrobial Resistance Unit, National Institute for Health and Welfare, Kiinamyllynkatu 13, FIN-20520 Turku, Finland.
J Antimicrob Chemother. 2012 Dec;67(12):2860-4. doi: 10.1093/jac/dks299. Epub 2012 Jul 31.
Carbapenemase-producing Enterobacteriaceae (CPE) are becoming a global problem; they are often resistant to nearly all available antibiotics. Here we report details on all Finnish CPE isolates found until the end of 2011: carbapenemase genes, travel history and multilocus sequence typing (MLST) data.
Enterobacteriaceae sent to the Antimicrobial Resistance Unit of the National Institute for Health and Welfare were tested for susceptibility to carbapenems, screened for carbapenemases by PCR and isolates with decreased susceptibility to carbapenems were tested for hydrolysis of imipenem. Carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolates were typed by MLST.
In all, 26 CPE strains were found from 25 patients: 10 with OXA-48-like enzymes, 5 with KPC, 4 with VIM, 3 with NDM, 3 with IMI/NMC-A and 1 with GES-14. The species were K. pneumoniae (n = 16), E. coli (n = 6), Enterobacter cloacae (n = 3) and Raoultella planticola (n = 1). Of the 25 patients, 18 had a known travel history/hospital transfer from abroad. Local spread/transmission was suspected in 2011, but there were no hospital outbreaks. The K. pneumoniae multilocus sequence types ST258, ST182, ST147, ST244, ST14, ST13, ST383, ST101 and ST15, and the E. coli sequence types ST38 and ST90 were found. Many of these are global epidemic clones.
CPE strains are increasingly found in Finland, but still at a very low prevalence.
产碳青霉烯酶肠杆菌科细菌（CPE）正在成为一个全球性问题；它们通常对几乎所有可用的抗生素都具有耐药性。在这里，我们报告截至 2011 年底在芬兰发现的所有 CPE 分离株的详细信息：碳青霉烯酶基因、旅行史和多位点序列分型（MLST）数据。
送往国家卫生和福利研究所抗菌药物耐药性部门的肠杆菌科被测试对碳青霉烯类药物的敏感性，通过 PCR 筛选碳青霉烯酶，对碳青霉烯类药物敏感性降低的分离株测试亚胺培南水解。产碳青霉烯酶的大肠埃希菌和肺炎克雷伯菌分离株通过 MLST 进行分型。
总共从 25 名患者中发现了 26 株 CPE 菌株：10 株带有 OXA-48 样酶，5 株带有 KPC，4 株带有 VIM，3 株带有 NDM，3 株带有 IMI/NMC-A 和 1 株带有 GES-14。这些物种是肺炎克雷伯菌（n=16）、大肠埃希菌（n=6）、阴沟肠杆菌（n=3）和植物罗伊氏菌（n=1）。在 25 名患者中，有 18 人有已知的旅行史/从国外转院。2011 年怀疑有本地传播/传播，但没有医院爆发。发现了肺炎克雷伯菌多位点序列类型 ST258、ST182、ST147、ST244、ST14、ST13、ST383、ST101 和 ST15，以及大肠埃希菌序列类型 ST38 和 ST90。其中许多是全球流行克隆。
CPE 菌株在芬兰的发现越来越多，但仍然非常低。
