Ehler W J, Cissik J H, Smith V C, Hubbard G B
Surgical Research, Wilford Hall USAF Medical Center/Clinical Investigations, Lackland AFB, TX 78236.
J Invest Surg. 1990;3(2):119-27. doi: 10.3109/08941939009140342.
Following right ventriculotomy, Gore-Tex PTFE vascular grafts were placed in eight neutered male, 6- to 8-week-old, 8- to 12-kg pigs. Ten to 14 months after surgery each pig was evaluated by right heart catheterization. The swine were sacrificed and the hearts were evaluated grossly and microscopically. Comparison of the mean derived cardiovascular hemodynamic parameters in this group with published data on swine and humans indicated normal cardiovascular physiology. Since there was no gradient across the patched areas, it appears that the patches had no adverse effects on the cardiovascular system of growing pigs over an approximately 1-year time period. In addition, the Gore-Tex appeared to be satisfactory for the repair of right ventricular outflow enlargement. Its relative ease of handling, configuration, and lack of aneurysm formation were advantages over other available materials. However, focal calcification and chronic inflammatory reaction did indicate the possibility of long-term prosthetic failure.
在对八只6至8周龄、体重8至12千克的去势雄性猪进行右心室切开术后，植入了戈尔特斯聚四氟乙烯血管移植物。术后10至14个月，对每头猪进行右心导管检查评估。然后处死这些猪，并对心脏进行大体和显微镜检查。将该组中得出的平均心血管血流动力学参数与已发表的猪和人类数据进行比较，表明心血管生理正常。由于修补区域没有压力阶差，似乎这些补片在大约1年的时间内对生长猪的心血管系统没有不良影响。此外，戈尔特斯补片似乎对于右心室流出道扩大的修复是令人满意的。其相对易于操作、形状以及无动脉瘤形成是优于其他可用材料的优点。然而，局灶性钙化和慢性炎症反应确实表明存在长期假体失败的可能性。
