Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, OH 44272, USA.
Bioorg Med Chem Lett. 2012 Sep 1;22(17):5675-8. doi: 10.1016/j.bmcl.2012.06.096. Epub 2012 Jul 15.
The serum and glucocorticoid regulated kinase-1 (SGK1) is part of the serine/threonine kinase family and has therapeutic potential in several neurodegenerative diseases such as ischemic stroke and Parkinson's disease. Here we use structure-based virtual screening to identify a novel ligand which inhibits SGK1 activity. The data presented here can be used for future scaffold hopping and possible drug development efforts.
血清和糖皮质激素调节激酶 1（SGK1）是丝氨酸/苏氨酸激酶家族的一部分，在几种神经退行性疾病中具有治疗潜力，如缺血性中风和帕金森病。在这里，我们使用基于结构的虚拟筛选来识别一种新型配体，该配体可抑制 SGK1 活性。这里呈现的数据可用于未来的支架跃迁和可能的药物开发工作。
