Department of Biology, Faculty of Science, Firat University, Elazig, Turkey.
Mol Nutr Food Res. 2012 Sep;56(9):1477-81. doi: 10.1002/mnfr.201200130. Epub 2012 Aug 1.
Cancer is one of the leading causes of death worldwide. Since dietary factors have been connected to a reduced risk of a diversity of human cancers, in this study we investigated the effects of tomato powder (TP) on the development of azoxymethane (AOM)-induced colorectal cancer in Wistar rats, and possible mechanism(s) by which TP shows its chemopreventive activity. Here we show that TP added to feed at 5% rate decreases the rate of aberrant crypt foci (ACF) and reduces the development of adenocarcinoma and growth of AOM-induced colorectal cancer in rats. In addition, we demonstrate that TP supplementation shows its chemopreventive activities through inhibition of cyclooxygenase-2 (COX-2) expression via NF-κB pathway and promotion of apoptosis, as well as regulating Nrf2/HO-1 signaling pathway in colorectal tissue of AOM-treated rats. Our findings identify an intimate connection between dietary supplementation of TP and the decreased risk of colorectal cancer in rats, and suggest that consumption of TP would be a natural candidate for the prevention of colorectal cancer in men.
癌症是全球主要死因之一。由于饮食因素与多种人类癌症的风险降低有关，因此在这项研究中，我们研究了番茄粉（TP）对 Wistar 大鼠氧化偶氮甲烷（AOM）诱导的结直肠癌发展的影响，以及 TP 发挥其化学预防活性的可能机制。在这里，我们表明，在饲料中添加 5%的 TP 可降低异常隐窝病灶（ACF）的发生率，并减少 AOM 诱导的大鼠结肠癌的腺癌形成和生长。此外，我们证明，TP 通过抑制 NF-κB 通路中的环氧化酶-2（COX-2）表达以及促进氧化偶氮甲烷处理大鼠结直肠组织中的细胞凋亡，同时调节 Nrf2/HO-1 信号通路，从而发挥其化学预防作用。我们的研究结果确定了在饮食中补充 TP 与降低大鼠结直肠癌风险之间的密切联系，并表明摄入 TP 可能是预防男性结直肠癌的天然候选物。
