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症状性静脉血栓栓塞症是一种与感染和免疫功能障碍相关的疾病。

Symptomatic venous thromboembolism is a disease related to infection and immune dysfunction.

机构信息

Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.

出版信息

Int J Med Sci. 2012;9(6):453-61. doi: 10.7150/ijms.4453. Epub 2012 Jul 26.

DOI:10.7150/ijms.4453
PMID:22859906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3410365/
Abstract

The characteristics of human genomics and cellular immune function between clinically symptomatic venous thromboembolism (VTE) and controls were systematically compared to explore the immunologic pathogenesis of VTE. Microarray assay showed the mRNA expressions of genes related to non-specific cellarer immune and cytokines were significantly down-regulated. Abnormal expressions of CD3+, CD4+, CD8+, NK marker CD16+56+, CD19 and aberrant CD4+/CD8+ ratio were detected in 54 among 56 patients. In PE patients, microarray assay revealed the imbalance in the expressions of genes related to the immune system. The expressions of genes related to non-specific immune cells and cytokines were markedly up-regulated and those associated with cellular immune were dramatically down-regulated. In VTE patients, cytological examination indicated the functions of NK cells were significantly compromised, and the antigen recognition and killing function of T cells markedly decreased. The consistence between genomic and cytological examination suggests the symptomatic VTE is closely associated with the infection and immune dysfunction.

摘要

对有临床症状的静脉血栓栓塞症（VTE）患者和对照组之间的人类基因组学和细胞免疫功能特征进行了系统比较，以探讨 VTE 的免疫学发病机制。微阵列分析显示，与非特异性细胞免疫和细胞因子相关的基因的 mRNA 表达显著下调。在 56 例患者中的 54 例中检测到 CD3+、CD4+、CD8+、NK 标记物 CD16+56+、CD19 和异常的 CD4+/CD8+比值的异常表达。在 PE 患者中，微阵列分析显示与免疫系统相关的基因表达失衡。与非特异性免疫细胞和细胞因子相关的基因表达明显上调，而与细胞免疫相关的基因表达明显下调。在 VTE 患者中，细胞学检查表明 NK 细胞的功能明显受损，T 细胞的抗原识别和杀伤功能明显降低。基因组学和细胞学检查的一致性表明，有症状的 VTE 与感染和免疫功能障碍密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/33de865097da/ijmsv09p0453g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/abeaff855ad9/ijmsv09p0453g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/1f39e8660594/ijmsv09p0453g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/127f302c4679/ijmsv09p0453g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/94a427b35ef7/ijmsv09p0453g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/388c32dbb77c/ijmsv09p0453g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/e77613ab2264/ijmsv09p0453g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/91c10c1cd3f1/ijmsv09p0453g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/1c6c3f308da1/ijmsv09p0453g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/33de865097da/ijmsv09p0453g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/abeaff855ad9/ijmsv09p0453g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/1f39e8660594/ijmsv09p0453g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/127f302c4679/ijmsv09p0453g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/94a427b35ef7/ijmsv09p0453g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/388c32dbb77c/ijmsv09p0453g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/e77613ab2264/ijmsv09p0453g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/91c10c1cd3f1/ijmsv09p0453g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/1c6c3f308da1/ijmsv09p0453g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ca/3410365/33de865097da/ijmsv09p0453g09.jpg

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本文引用的文献

1
Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.非外科患者的 VTE 预防：抗血栓治疗和血栓预防，第 9 版：美国胸科医师学会基于证据的临床实践指南。
Chest. 2012 Feb;141(2 Suppl):e195S-e226S. doi: 10.1378/chest.11-2296.
2
T cell-mediated immune deficiency or compromise in patients with CTEPH.慢性血栓栓塞性肺动脉高压（CTEPH）患者的T细胞介导的免疫缺陷或损害
Am J Respir Crit Care Med. 2011 Feb 1;183(3):417-8. doi: 10.1164/ajrccm.183.3.417.
3
Severe acute respiratory syndrome and venous thromboembolism in multiple organs.
COVID-19 阳性住院患者的促血栓形成环境、血栓形成事件和预防性抗凝治疗：综述。
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221074353. doi: 10.1177/10760296221074353.
4
Venous thromboembolism is linked to severity of disease in COVID-19 patients: A systematic literature review and exploratory meta-analysis.静脉血栓栓塞与 COVID-19 患者的疾病严重程度相关：系统文献回顾和探索性荟萃分析。
Int J Clin Pract. 2021 Dec;75(12):e14910. doi: 10.1111/ijcp.14910. Epub 2021 Sep 28.
5
Immunological analysis and differential genes screening of venous thromboembolism.静脉血栓栓塞症的免疫分析与差异基因筛选。
Hereditas. 2021 Jan 2;158(1):2. doi: 10.1186/s41065-020-00166-6.
6
Venous Thromboembolism in COVID-19.COVID-19 相关静脉血栓栓塞症。
Thromb Haemost. 2020 Dec;120(12):1642-1653. doi: 10.1055/s-0040-1718532. Epub 2020 Oct 24.
7
The role of bone marrow-derived cells in venous thromboembolism.骨髓源性细胞在静脉血栓栓塞中的作用。
Int J Biochem Cell Biol. 2020 Nov;128:105850. doi: 10.1016/j.biocel.2020.105850. Epub 2020 Sep 17.
8
Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia.新型冠状病毒肺炎重型患者静脉血栓栓塞症发病情况。
J Thromb Haemost. 2020 Jun;18(6):1421-1424. doi: 10.1111/jth.14830. Epub 2020 May 6.
9
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10
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4
Compromised T-cell immunity and virus-like structure in a patient with pulmonary hypertension.一名肺动脉高压患者的T细胞免疫受损及病毒样结构
Am J Respir Crit Care Med. 2010 Aug 1;182(3):434-5. doi: 10.1164/ajrccm.182.3.434.
5
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Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1672-8. doi: 10.1161/ATVBAHA.109.198473. Epub 2010 May 13.
6
ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association.美国心脏病学会基金会/美国心脏协会2009年肺动脉高压专家共识文件：美国心脏病学会基金会专家共识文件特别工作组及美国心脏协会报告：与美国胸科医师学会、美国胸科学会及肺动脉高压协会合作制定。
Circulation. 2009 Apr 28;119(16):2250-94. doi: 10.1161/CIRCULATIONAHA.109.192230. Epub 2009 Mar 30.
7
Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).静脉血栓栓塞的预防：美国胸科医师学会循证临床实践指南（第8版）
Chest. 2008 Jun;133(6 Suppl):381S-453S. doi: 10.1378/chest.08-0656.
8
A 10-year analysis of venous thromboembolism on the surgical service: the effect of practice guidelines for prophylaxis.外科服务中静脉血栓栓塞的10年分析：预防实践指南的影响
Surgery. 2008 Jul;144(1):3-11. doi: 10.1016/j.surg.2008.04.004.
9
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Nat Immunol. 2008 Jan;9(1):63-72. doi: 10.1038/ni1547. Epub 2007 Dec 2.
10
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