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新型大环内酯类抗生素的差异杀锥虫活性；与遗传谱系的相关性。

Differential trypanocidal activity of novel macrolide antibiotics; correlation to genetic lineage.

机构信息

Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid, Spain.

出版信息

PLoS One. 2012;7(7):e40901. doi: 10.1371/journal.pone.0040901. Epub 2012 Jul 31.

DOI:10.1371/journal.pone.0040901
PMID:22859958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3409201/
Abstract

Here we report the systematic study of the anti-trypanocidal activity of some new products derived from S. diastatus on 14 different T. cruzi strains spanning the six genetic lineages of T. cruzi. As the traditional growth inhibition curves giving similar IC(50) showed great differences on antibiotic and lineage tested, we decided to preserve the wealth of information derived from each inhibition curve and used an algorithm related to potency of the drugs, combined in a matrix data set used to generate a cluster tree. The cluster thus generated based just on drug susceptibility data closely resembles the phylogenies of the lineages derived from genetic data and provides a novel approach to correlate genetic data with phenotypes related to pathogenesis of Chagas disease. Furthermore we provide clues on the drugs mechanism of action.

摘要

在这里，我们报告了对来自 S. diastatus 的一些新产品在 14 种不同的 T. cruzi 株上的抗锥虫活性的系统研究，这些株涵盖了 T. cruzi 的六个遗传谱系。由于传统的生长抑制曲线在抗生素和谱系测试方面表现出了很大的差异，我们决定保留从每条抑制曲线中获得的丰富信息，并使用一种与药物效力相关的算法，将其组合到一个矩阵数据集，以生成聚类树。仅基于药物敏感性数据生成的聚类与遗传数据衍生的谱系的系统发育非常相似，为将遗传数据与与恰加斯病发病机制相关的表型相关联提供了一种新方法。此外，我们还提供了有关药物作用机制的线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/928486a0b9b8/pone.0040901.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/aaf3dc279802/pone.0040901.g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/d3bbdd634420/pone.0040901.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/48ba4c0cb134/pone.0040901.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/7893cefe20cd/pone.0040901.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/928486a0b9b8/pone.0040901.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/aaf3dc279802/pone.0040901.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/11b747039f2a/pone.0040901.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/d3bbdd634420/pone.0040901.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/48ba4c0cb134/pone.0040901.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/7893cefe20cd/pone.0040901.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6958/3409201/928486a0b9b8/pone.0040901.g006.jpg

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