恰加斯病的慢性胃肠道表现。
The chronic gastrointestinal manifestations of Chagas disease.
机构信息
Departamento de Anatomia e Cirurgia, Universidade de São Paulo - Ribeirão Preto/SP, Brazil.
出版信息
Clinics (Sao Paulo). 2009;64(12):1219-24. doi: 10.1590/S1807-59322009001200013.
Abstract
Chagas disease is an infectious disease caused by the protozoan Trypanosoma cruzi. The disease mainly affects the nervous system, digestive system and heart. The objective of this review is to revise the literature and summarize the main chronic gastrointestinal manifestations of Chagas disease. The chronic gastrointestinal manifestations of Chagas disease are mainly a result of enteric nervous system impairment caused by T. cruzi infection. The anatomical locations most commonly described to be affected by Chagas disease are salivary glands, esophagus, lower esophageal sphincter, stomach, small intestine, colon, gallbladder and biliary tree. Chagas disease has also been studied in association with Helicobacter pylori infection, interstitial cells of Cajal and the incidence of gastrointestinal cancer.
摘要
恰加斯病是一种由原生动物克氏锥虫引起的传染病。该疾病主要影响神经系统、消化系统和心脏。本综述的目的是复习文献并总结恰加斯病的主要慢性胃肠道表现。恰加斯病的慢性胃肠道表现主要是由克氏锥虫感染引起的肠神经系统损伤所致。描述的最常受恰加斯病影响的解剖部位是唾液腺、食管、食管下括约肌、胃、小肠、结肠、胆囊和胆道。恰加斯病还与幽门螺杆菌感染、Cajal 间质细胞和胃肠道癌症的发生有关。
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本文引用的文献
1
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Ann Afr Med. 2008 Sep;7(3):141-8. doi: 10.4103/1596-3519.55662.
2
Parotid gland enlargement in eating disorders: an insensitive sign?
Eat Weight Disord. 2008 Dec;13(4):e79-83. doi: 10.1007/BF03327509.
3
Interstitial cells of Cajal reduce in number in recto-sigmoid Hirschsprung's disease and total colonic aganglionosis.
Neurosci Lett. 2009 Feb 27;451(3):208-11. doi: 10.1016/j.neulet.2009.01.015. Epub 2009 Jan 13.
4
Endoscopic and surgical treatments for achalasia: a systematic review and meta-analysis.
Ann Surg. 2009 Jan;249(1):45-57. doi: 10.1097/SLA.0b013e31818e43ab.
5
Interstitial cells of Cajal in the gut--a gastroenterologist's point of view.
World J Gastroenterol. 2008 Nov 7;14(41):6285-8. doi: 10.3748/wjg.14.6285.
6
Prevalence of rectoanal inhibitory reflex in chagasic megacolon.
Arq Gastroenterol. 2008 Apr-Jun;45(2):128-31. doi: 10.1590/s0004-28032008000200007.
7
Interstitial cells of Cajal in chagasic megaesophagus.
Ann Diagn Pathol. 2008 Aug;12(4):271-274. doi: 10.1016/j.anndiagpath.2007.12.002. Epub 2008 Apr 18.
8
Surgical treatment of Chagas megacolon. Critical analysis of outcome in operative methods.
Acta Cir Bras. 2008;23 Suppl 1:83-92; discussion 92. doi: 10.1590/s0102-86502008000700015.
9
Interstitial cells of Cajal in health and disease.
Neurogastroenterol Motil. 2008 May;20 Suppl 1:54-63. doi: 10.1111/j.1365-2982.2008.01109.x.
10
Novel concepts in the diagnosis, pathophysiology and management of idiopathic megabowel.
Colorectal Dis. 2008 Jul;10(6):531-8; discussion 538-40. doi: 10.1111/j.1463-1318.2007.01457.x. Epub 2008 Mar 18.
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