Dinis D V, Schapira A
Servicio de Medicina Interna, Hospital Central de Maputo, Mozambique.
Bull Soc Pathol Exot. 1990;83(4):521-7; discussion 528.
To compare the efficacy and side-effects of two therapeutic regimens for chloroquine-resistant falciparum malaria, a randomized study was carried out in 69 patients in Maputo Central Hospital in 1986-1987. The two treatments were sulfadoxine 25 mg/kg + pyrimethamine 1.25 mg/kg as a single dose (S + P) and amodiaquine 10 + 10 + 5 mg/kg over three days with sulfadoxine + pyrimethamine on the third day (A + S + P). The cure rate was 25/29 (86%) with S + P and 27/30 (90%) with A + S + P. No serious side-effects were observed. The probably slightly higher cure rate with the triple combination is hardly of clinical importance in semi-immune patients, but may theoretically help retard the development of resistance to sulfadoxine-pyrimethamine. This point and the question of the incidence of side-effects with the two regimens should be made the object of an epidemiological study.
为比较两种治疗耐氯喹恶性疟治疗方案的疗效和副作用，1986年至1987年在马普托中心医院对69例患者进行了一项随机研究。两种治疗方法分别为：磺胺多辛25mg/kg + 乙胺嘧啶1.25mg/kg单剂量给药（S + P），以及阿莫地喹10 + 10 + 5mg/kg分三天给药，第三天加用磺胺多辛 + 乙胺嘧啶（A + S + P）。S + P组的治愈率为25/29（86%），A + S + P组为27/30（90%）。未观察到严重副作用。三联疗法的治愈率可能略高，但在半免疫患者中这在临床上几乎没有重要意义，但理论上可能有助于延缓对磺胺多辛 - 乙胺嘧啶耐药性的发展。这一点以及两种治疗方案的副作用发生率问题应成为一项流行病学研究的对象。
