Huang O L, Ouyang W C, Zhou J X, Wu Z, Zhang K Y, Huang J K, Cai X Z, Pang X J, Fu S G, Wang X F
Bull World Health Organ. 1988;66(3):353-8.
The study was carried out in 1985-86 in Hainan Island where Plasmodium falciparum is resistant to chloroquine. Fifty cases of falciparum malaria were treated with 1800 mg amodiaquine for 3 days: the cure rate was 65.3%, and the mean time to clear fever and asexual parasitaemia was 30.7 and 60.3 hours, respectively; 34.7% of cases showed RI or RII recrudescence, and one patient's temperature did not come down to normal within 7 days.Twenty-one cases were treated with sulfadoxine-pyrimethamine (1500 mg and 75 mg, respectively): 19 were cured, I showed RI and another had an S or RI response; the mean time for fever control was 56.1 hours.Fifty cases were treated with amodiaquine plus sulfadoxine and 49 received amodiaquine plus sulfadoxine-pyrimethamine: the cure rate was 97.9% and 100%, respectively; the mean time for fever clearance was 25.0 and 25.7 hours and for parasite clearance 57.1 and 52.8 hours, respectively. These drug combinations gave much better results for cure and for symptom control than amodiaquine or sulfadoxine-pyrimethamine alone, and may be considered for treatment of chloroquine-resistant falciparum malaria.
该研究于1985 - 1986年在海南岛开展，当地恶性疟原虫对氯喹耐药。50例恶性疟患者接受1800毫克氨酚喹治疗3天：治愈率为65.3%，退热和无性疟原虫血症清除的平均时间分别为30.7小时和60.3小时；34.7%的病例出现RI或RII复发，1例患者体温在7天内未恢复正常。21例患者接受周效磺胺 - 乙胺嘧啶治疗（分别为1500毫克和75毫克）：19例治愈，1例出现RI，另1例有S或RI反应；控制发热的平均时间为56.1小时。50例患者接受氨酚喹加周效磺胺治疗，49例接受氨酚喹加周效磺胺 - 乙胺嘧啶治疗：治愈率分别为97.9%和100%；退热平均时间分别为25.0小时和25.7小时，疟原虫清除平均时间分别为57.1小时和52.8小时。这些药物组合在治愈和症状控制方面比单独使用氨酚喹或周效磺胺 - 乙胺嘧啶效果好得多，可考虑用于治疗氯喹耐药的恶性疟。
