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[同时或短间隔进行的抗霍乱疫苗接种对黄热病免疫的抑制作用。是真实存在还是臆想?一项回顾性研究的结果]

[The inhibiting effect of anticholera vaccination carried out simultaneously or at short intervals on yellow fever immunization. Is it real or assumed? Results of a retrospective study].

作者信息

Poveda J D, Raccurt C P, Le Fur R, M'Bailara L, Malvy J M, Le Bras M, Saliou P, Fleury H J

机构信息

Laboratoire de Virologie, Université de Bordeaux II.

出版信息

Bull Soc Pathol Exot. 1990;83(4):529-35; discussion 535-6.

PMID:2286006
Abstract

121 serum samples from African adults previously immunised with 17 D yellow fever vaccine alone (control group) or simultaneous yellow fever and cholera vaccines were tested for yellow fever antibodies by seroneutralization and haemagglutination inhibition assays. Comparison of the rates of seroconversion and antibody titers between the groups vaccinated the same day or into a short (less than or equal to 10 days) or a long time interval with both vaccines and the control group gave no significant difference. The association of cholera and yellow fever vaccines do not influence the long-term efficiency of yellow fever vaccination.

摘要

对121份来自非洲成年人的血清样本进行检测,这些成年人之前单独接种了17D黄热病疫苗(对照组)或同时接种了黄热病疫苗和霍乱疫苗,通过血清中和试验和血凝抑制试验检测黄热病抗体。比较同一天接种两种疫苗的组、短时间间隔(小于或等于10天)接种两种疫苗的组、长时间间隔接种两种疫苗的组与对照组之间的血清转化率和抗体滴度,结果无显著差异。霍乱疫苗和黄热病疫苗联合接种不影响黄热病疫苗的长期效力。

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