Division of Pediatric Hematology, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA.
N Engl J Med. 2011 Jan 13;364(2):146-56. doi: 10.1056/NEJMct1004810.
A 16-year-old boy with sickle cell anemia undergoes routine screening with transcranial Doppler ultrasonography to assess the risk of stroke. This examination shows an abnormally elevated blood-flow velocity in the middle cerebral artery. The hemoglobin level is 7.2 g per deciliter, the reticulocyte count is 12.5%, and the fetal hemoglobin level is 8.0%. Long-term treatment with red-cell transfusion is initiated to prevent stroke. A hematologist recommends prophylactic iron-chelating therapy.
一位 16 岁的镰状细胞贫血男孩接受经颅多普勒超声检查进行常规筛查，以评估中风风险。该检查显示大脑中动脉的血流速度异常升高。血红蛋白水平为每分升 7.2 克，网织红细胞计数为 12.5%，胎儿血红蛋白水平为 8.0%。开始进行长期红细胞输血治疗以预防中风。血液科医生建议进行预防性铁螯合治疗。
