Turula M, Kaprio J, Rissanen A, Koskenvuo M
Department of Public Health, University of Helsinki, Finland.
Diabetes Res Clin Pract. 1990;10 Suppl 1:S33-6. doi: 10.1016/0168-8227(90)90137-i.
We estimated genetic and environmental variance of BMI among 7245 non-pregnant MZ and DZ pairs of the same sex from the population-based Finnish Twin Cohort. The contributions of additive genetic effects, shared and non-shared environmental effects on age-adjusted BMI-variance were estimated by LISREL structural equation models. Genetic effects contribute 72% in men and 66.4% in non-pregnant women of total variance, while 27.8% of variance among men and 33.6% among women is due to non-shared environmental effects. Shared environmental effects were nonsignificant (0% for women and 0.2% for men). Similar values were obtained for hereditary and non-shared environmental effects, when shared environmental effects were not included in the model. The inclusion of pregnant women did not substantially change heritability estimates.
我们从芬兰全国双胞胎队列中估算了7245对同性非孕单卵双胞胎(MZ)和异卵双胞胎(DZ)的体重指数(BMI)的遗传和环境方差。通过LISREL结构方程模型估算了加性遗传效应、共同和非共同环境效应对年龄校正后的BMI方差的贡献。遗传效应在男性总方差中占72%,在非孕女性中占66.4%,而男性方差的27.8%和女性方差的33.6%归因于非共同环境效应。共同环境效应不显著(女性为0%,男性为0.2%)。当模型中不包括共同环境效应时,遗传和非共同环境效应获得了相似的值。纳入孕妇并没有实质性改变遗传度估计值。