Lehmann P, Schäfer T, Bolsen K, Goerz G
Hautklinik Heinrich-Heine-Universität Düsseldorf.
Derm Beruf Umwelt. 1990 Sep-Oct;38(5):148-9, 151-4.
The Effect of UV-Irradiation on the Hexachlorobenzene-induced Porphyria in an Experimental Animal Model Hexachlorobenzene is able to induce in humans and different animal species a hepatic porphyria, which is comparable to porphyria cutanea tarda. We studied whether hexachlorobenzene feeding could induce this porphyria also in hairless rats (Rowett-Nude), as these are suitable for photobiologic studies. After development of hepatic porphyria the rats were irradiated either with UV-A or UV-B light. Biochemical effects on the porphyrin metabolism and clinical as well as histologic skin changes were examined. In the liver of the porphyric rats, UV-A and UV-B irradiation induced increased aminolevulinic acid synthase activity accompanied with augmentation of hepatic porphyrin content. UV-A or UV-B irradiation also lead to increased total porphyrin contents in the skin of porphyric compared to non-irradiated animals. Clinically and histologically, however, only UV-A irradiation induced lesions, which were comparable to skin manifestations of porphyria cutanea tarda.
紫外线照射对实验动物模型中六氯苯诱导的卟啉症的影响 六氯苯能够在人类和不同动物物种中诱发一种肝性卟啉症，该病症与迟发性皮肤卟啉症相似。我们研究了喂食六氯苯是否也能在无毛大鼠（罗威特裸鼠）中诱发这种卟啉症，因为这些大鼠适合进行光生物学研究。在肝性卟啉症形成后，对大鼠进行紫外线A或紫外线B照射。检测了对卟啉代谢的生化影响以及临床和组织学上的皮肤变化。在患卟啉症大鼠的肝脏中，紫外线A和紫外线B照射均诱导氨基乙酰丙酸合成酶活性增加，同时肝脏卟啉含量增加。与未照射的动物相比，紫外线A或紫外线B照射还导致患卟啉症大鼠皮肤中的总卟啉含量增加。然而，在临床和组织学上，只有紫外线A照射会诱发病变，这些病变与迟发性皮肤卟啉症的皮肤表现相似。
