Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
J Cell Mol Med. 2012 Dec;16(12):2894-909. doi: 10.1111/j.1582-4934.2012.01612.x.
Eph receptor tyrosine kinases and their ephrin ligands are involved in various signalling pathways and mediate critical steps of a wide variety of physiological and pathological processes. Increasing experimental evidence demonstrates that both Eph receptor and ephrin ligands are overexpressed in a number of human tumours, and are associated with tumour growth, invasiveness and metastasis. In this regard, the Eph/ephrin system provides the foundation for potentially exciting new targets for anticancer therapies for Eph-expressing tumours. The purpose of this review is to outline current advances in the role of Eph receptors and ephrin ligands in cancer, and to discuss novel therapeutic approaches of anticancer therapies.
Eph 受体酪氨酸激酶及其 Ephrin 配体参与多种信号通路，并介导多种生理和病理过程的关键步骤。越来越多的实验证据表明，Eph 受体和 Ephrin 配体在许多人类肿瘤中过度表达，并与肿瘤生长、侵袭和转移有关。在这方面，Eph/ephrin 系统为 Eph 表达肿瘤的潜在抗癌治疗提供了新的有吸引力的靶点基础。本文旨在概述 Eph 受体和 Ephrin 配体在癌症中的作用的最新进展，并讨论新型抗癌治疗方法。
