Buchanan Bob B, Holmgren Arne, Jacquot Jean-Pierre, Scheibe Renate
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.
Biochim Biophys Acta. 2012 Nov;1820(11):1822-9. doi: 10.1016/j.bbagen.2012.07.006. Epub 2012 Jul 27.
Discovered 50 years ago as a hydrogen donor for the reduction of ribonucleotides, thioredoxin is currently recognized as a protein central to the regulation of multiple processes in the cell. Two meetings separated by a period of 30 years serve as benchmarks for assessing this transition-the first held in Berkeley (California) in 1981 and the other convened in 2011 in Sant Feliu de Guixols (Spain). The four of us contributing this article attended both meetings and thus have witnessed the development of the thioredoxin field and its notable extension in unanticipated new directions. In this Perspective we briefly recount the unfolding of this remarkable story.
50年前，硫氧还蛋白作为还原核糖核苷酸的氢供体被发现，目前它被认为是细胞中多种过程调节的核心蛋白质。相隔30年的两次会议成为评估这一转变的基准——第一次会议于1981年在伯克利（加利福尼亚州）举行，另一次于2011年在圣费利乌德吉乔尔斯（西班牙）召开。撰写本文的我们四人都参加了这两次会议，因此见证了硫氧还蛋白领域的发展及其在意外新方向上的显著扩展。在这篇综述中，我们简要叙述了这个非凡故事的展开过程。
