22q11.2 缺失综合征患者脑白质部分各向异性分数和轴向弥散率降低：一项初步研究。
Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study.
机构信息
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Schizophr Res. 2012 Oct;141(1):35-9. doi: 10.1016/j.schres.2012.06.032. Epub 2012 Aug 3.
Abstract
Individuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group of matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) and Axial Diffusivity (AD; measure of axonal integrity) in WM underlying the left parietal lobe. No changes in Radial Diffusivity (RD; measure of myelin integrity) were observed. Of note, studies in chronic schizophrenia patients report reduced FA, no changes in AD, and increases in RD in WM. Our findings suggest different WM microstructural pathology in 22q11.2DS than in patients with schizophrenia.
摘要
22q11.2 缺失综合征（22q11.2DS）患者有 30%的精神分裂症发病率。我们使用基于束流的空间统计学（TBSS），将没有精神分裂症的 22q11.2DS 患者的脑白质（WM）与一组匹配的健康对照组进行比较。我们发现左顶叶下 WM 的各向异性分数（FA）和轴向弥散度（AD；轴突完整性的测量）局部减少。没有观察到径向弥散度（RD；髓鞘完整性的测量）的变化。值得注意的是，慢性精神分裂症患者的研究报告 WM 中的 FA 减少，AD 没有变化，RD 增加。我们的研究结果表明，22q11.2DS 患者的 WM 微观结构病理学与精神分裂症患者不同。
相似文献
1
Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study.22q11.2 缺失综合征患者脑白质部分各向异性分数和轴向弥散率降低：一项初步研究。
Schizophr Res. 2012 Oct;141(1):35-9. doi: 10.1016/j.schres.2012.06.032. Epub 2012 Aug 3.
2
Genetic contributions to changes of fiber tracts of ventral visual stream in 22q11.2 deletion syndrome.22q11.2 缺失综合征中腹侧视觉流纤维束变化的遗传贡献。
Brain Imaging Behav. 2013 Sep;7(3):316-25. doi: 10.1007/s11682-013-9232-5.
3
Atlas-based white matter analysis in individuals with velo-cardio-facial syndrome (22q11.2 deletion syndrome) and unaffected siblings.基于图谱的脑白质分析在患有颅面心综合征（22q11.2 缺失综合征）的个体和无相关疾病的兄弟姐妹中的应用。
Behav Brain Funct. 2012 Aug 1;8:38. doi: 10.1186/1744-9081-8-38.
4
Machine-learning classification of 22q11.2 deletion syndrome: A diffusion tensor imaging study.22q11.2 缺失综合征的机器学习分类：一项弥散张量成像研究。
Neuroimage Clin. 2017 May 11;15:832-842. doi: 10.1016/j.nicl.2017.04.029. eCollection 2017.
5
Reduced white matter integrity and cognitive deficit in never-medicated chronic schizophrenia: a diffusion tensor study using TBSS.使用 TBSS 进行弥散张量研究：未经治疗的慢性精神分裂症患者的脑白质完整性降低和认知缺陷
Behav Brain Res. 2013 Sep 1;252:157-63. doi: 10.1016/j.bbr.2013.05.061. Epub 2013 Jun 6.
6
Abnormalities in brain white matter in adolescents with 22q11.2 deletion syndrome and psychotic symptoms.22q11.2 缺失综合征伴精神病症状青少年的脑白质异常。
Brain Imaging Behav. 2017 Oct;11(5):1353-1364. doi: 10.1007/s11682-016-9602-x.
7
White matter microstructural deficits in 22q11.2 deletion syndrome.22q11.2 缺失综合征中的脑白质微观结构缺陷。
Psychiatry Res Neuroimaging. 2017 Oct 30;268:35-44. doi: 10.1016/j.pscychresns.2017.08.001. Epub 2017 Aug 24.
8
White matter microstructural abnormalities in girls with chromosome 22q11.2 deletion syndrome, Fragile X or Turner syndrome as evidenced by diffusion tensor imaging.应用弥散张量成像技术研究 22q11.2 号染色体缺失综合征、脆性 X 综合征或特纳综合征女孩的脑白质微观结构异常。
Neuroimage. 2013 Nov 1;81:441-454. doi: 10.1016/j.neuroimage.2013.04.028. Epub 2013 Apr 18.
9
White matter microstructural abnormalities of the cingulum bundle in youths with 22q11.2 deletion syndrome: associations with medication, neuropsychological function, and prodromal symptoms of psychosis.22q11.2缺失综合征青少年扣带束的白质微结构异常：与药物治疗、神经心理功能及精神病前驱症状的关联
Schizophr Res. 2015 Jan;161(1):76-84. doi: 10.1016/j.schres.2014.07.010. Epub 2014 Jul 25.
10
Distinct white-matter aberrations in 22q11.2 deletion syndrome and patients at ultra-high risk for psychosis.22q11.2缺失综合征及超高精神病风险患者中独特的白质异常。
Psychol Med. 2016 Aug;46(11):2299-311. doi: 10.1017/S0033291716000970. Epub 2016 May 19.
引用本文的文献
1
Structural Connectivity and Emotion Recognition Impairment in Children and Adolescents with Chromosome 22q11.2 Deletion Syndrome.22q11.2 缺失综合征患儿和青少年的结构连接和情绪识别障碍。
J Autism Dev Disord. 2023 Oct;53(10):4021-4034. doi: 10.1007/s10803-022-05675-z. Epub 2022 Aug 2.
2
Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study.22q11.2 缺失综合征患者脑白质微观结构的改变：一项多中心弥散张量成像研究。
Mol Psychiatry. 2020 Nov;25(11):2818-2831. doi: 10.1038/s41380-019-0450-0. Epub 2019 Jul 29.
3
Genetic risk for schizophrenia and developmental delay is associated with shape and microstructure of midline white-matter structures.精神分裂症和发育迟缓的遗传风险与中线白质结构的形状和微观结构有关。
Transl Psychiatry. 2019 Feb 25;9(1):102. doi: 10.1038/s41398-019-0440-7.
4
Psychiatric and Cognitive Symptoms Associated with Niemann-Pick Type C Disease: Neurobiology and Management.与尼曼-匹克 C 型疾病相关的精神和认知症状：神经生物学与管理。
CNS Drugs. 2019 Feb;33(2):125-142. doi: 10.1007/s40263-018-0599-0.
5
Frontal dysconnectivity in 22q11.2 deletion syndrome: an atlas-based functional connectivity analysis.22q11.2 缺失综合征中的额连接异常：基于图谱的功能连接分析。
Behav Brain Funct. 2018 Jan 20;14(1):2. doi: 10.1186/s12993-018-0134-y.
6
White matter microstructural deficits in 22q11.2 deletion syndrome.22q11.2 缺失综合征中的脑白质微观结构缺陷。
Psychiatry Res Neuroimaging. 2017 Oct 30;268:35-44. doi: 10.1016/j.pscychresns.2017.08.001. Epub 2017 Aug 24.
7
Machine-learning classification of 22q11.2 deletion syndrome: A diffusion tensor imaging study.22q11.2 缺失综合征的机器学习分类：一项弥散张量成像研究。
Neuroimage Clin. 2017 May 11;15:832-842. doi: 10.1016/j.nicl.2017.04.029. eCollection 2017.
8
Visual memory profile in 22q11.2 microdeletion syndrome: are there differences in performance and neurobiological substrates between tasks linked to ventral and dorsal visual brain structures? A cross-sectional and longitudinal study.22q11.2微缺失综合征的视觉记忆特征：与腹侧和背侧视觉脑结构相关的任务在表现和神经生物学基础上是否存在差异？一项横断面和纵向研究。
J Neurodev Disord. 2016 Nov 10;8:41. doi: 10.1186/s11689-016-9174-5. eCollection 2016.
9
Abnormalities in brain white matter in adolescents with 22q11.2 deletion syndrome and psychotic symptoms.22q11.2 缺失综合征伴精神病症状青少年的脑白质异常。
Brain Imaging Behav. 2017 Oct;11(5):1353-1364. doi: 10.1007/s11682-016-9602-x.
10
Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders.自闭症谱系障碍中广泛存在的白质微观结构紊乱。
J Autism Dev Disord. 2019 Jul;49(7):2664-2674. doi: 10.1007/s10803-016-2803-8.
本文引用的文献
1
Alterations in white matter evident before the onset of psychosis.精神分裂症发病前的脑白质改变。
Schizophr Bull. 2012 Nov;38(6):1170-9. doi: 10.1093/schbul/sbs053. Epub 2012 Apr 3.
2
Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia.精神分裂症患者前额叶-顶叶有效连接减少与工作记忆缺陷。
J Neurosci. 2012 Jan 4;32(1):12-20. doi: 10.1523/JNEUROSCI.3405-11.2012.
3
White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescents.22q11 缺失综合征的脑白质微观结构：对儿童和青少年的扩散张量成像和基于体素的形态计量学的初步研究。
J Neurodev Disord. 2010 Jun;2(2):77-92. doi: 10.1007/s11689-010-9043-6. Epub 2010 Mar 5.
4
White matter abnormalities in adults with 22q11 deletion syndrome with and without schizophrenia.22q11 缺失综合征成人伴或不伴精神分裂症的脑白质异常。
Schizophr Res. 2011 Oct;132(1):75-83. doi: 10.1016/j.schres.2011.07.017. Epub 2011 Aug 9.
5
Voxel-based morphometry (VBM) studies in schizophrenia-can white matter changes be reliably detected with VBM?基于体素的形态测量学（VBM）研究在精神分裂症中的应用——VBM 能否可靠地检测到脑白质变化？
Psychiatry Res. 2011 Aug 30;193(2):65-70. doi: 10.1016/j.pscychresns.2011.01.009.
6
Association of schizophrenia in 22q11.2 deletion syndrome and gray matter volumetric deficits in the superior temporal gyrus.22q11.2 缺失综合征伴发精神分裂症与颞上回灰质体积减少有关。
Am J Psychiatry. 2011 May;168(5):522-9. doi: 10.1176/appi.ajp.2010.10081230. Epub 2011 Mar 1.
7
Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords.径向扩散率可预测多发性硬化症离体脊髓中的脱髓鞘。
Neuroimage. 2011 Apr 15;55(4):1454-60. doi: 10.1016/j.neuroimage.2011.01.007. Epub 2011 Jan 13.
8
Neuroanatomic predictors to prodromal psychosis in velocardiofacial syndrome (22q11.2 deletion syndrome): a longitudinal study.神经解剖学预测物与 velocardiofacial 综合征（22q11.2 缺失综合征）前驱期精神病：一项纵向研究。
Biol Psychiatry. 2011 May 15;69(10):945-52. doi: 10.1016/j.biopsych.2010.10.027. Epub 2010 Dec 31.
9
Similar white matter aberrations in children with autism and their unaffected siblings: a diffusion tensor imaging study using tract-based spatial statistics.自闭症儿童及其未受影响的兄弟姐妹存在类似的白质异常：一项使用基于束的空间统计学的扩散张量成像研究。
Arch Gen Psychiatry. 2010 Oct;67(10):1052-60. doi: 10.1001/archgenpsychiatry.2010.123.
10
Three phases of DiGeorge/22q11 deletion syndrome pathogenesis during brain development: patterning, proliferation, and mitochondrial functions of 22q11 genes.脑发育过程中迪乔治/22q11缺失综合征发病机制的三个阶段：22q11基因的模式形成、增殖及线粒体功能
Int J Dev Neurosci. 2011 May;29(3):283-94. doi: 10.1016/j.ijdevneu.2010.08.005. Epub 2010 Sep 15.
Zotero 插件