Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Schizophr Res. 2012 Oct;141(1):35-9. doi: 10.1016/j.schres.2012.06.032. Epub 2012 Aug 3.
Individuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group of matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) and Axial Diffusivity (AD; measure of axonal integrity) in WM underlying the left parietal lobe. No changes in Radial Diffusivity (RD; measure of myelin integrity) were observed. Of note, studies in chronic schizophrenia patients report reduced FA, no changes in AD, and increases in RD in WM. Our findings suggest different WM microstructural pathology in 22q11.2DS than in patients with schizophrenia.
22q11.2 缺失综合征（22q11.2DS）患者有 30%的精神分裂症发病率。我们使用基于束流的空间统计学（TBSS），将没有精神分裂症的 22q11.2DS 患者的脑白质（WM）与一组匹配的健康对照组进行比较。我们发现左顶叶下 WM 的各向异性分数（FA）和轴向弥散度（AD；轴突完整性的测量）局部减少。没有观察到径向弥散度（RD；髓鞘完整性的测量）的变化。值得注意的是，慢性精神分裂症患者的研究报告 WM 中的 FA 减少，AD 没有变化，RD 增加。我们的研究结果表明，22q11.2DS 患者的 WM 微观结构病理学与精神分裂症患者不同。
