囊性纤维化患儿的维生素 D。
Vitamin D in children with cystic fibrosis.
机构信息
Paediatric Respiratory Secretaries, Old Children's Outpatients Department, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
出版信息
Arch Dis Child. 2012 Nov;97(11):982-4. doi: 10.1136/archdischild-2011-301398. Epub 2012 Aug 4.
PURPOSE
The Cystic Fibrosis Trust in 2007 published a recommended target of 75-150 nmol/L for 25-hydroxyvitamin D (25-OHD). In 2008 we found that only 10% of pancreatic insufficient (PI) children met this target. An increase in supplementation was implemented and a repeat audit performed in 2010.
METHODS
PI children ≥1 year under sole-care in our regional centre were included. Vitamin D3 supplementation increased by >450% to either 3800 IU/day liquid or 800 IU daily plus 20,000 IU weekly tablets. In 2010 pancreatic sufficient (PS) children were also audited separately.
RESULTS
The median 25-OHD level increased from 51.5 nmol/L in 2008 (n=78, 10% >75 nmol/L) to 72 nmol/L in 2010 (n=72, 51% >75 nmol/L), p<0.0001. In PS children (n=15 in 2010) 87% had 25-OHD levels <75 nmol/L.
CONCLUSIONS
A substantial increase in supplementation led to a significant increase in 25-OHD levels but around half still failed to reach the recommended target.
目的
囊性纤维化信托基金会于 2007 年发布了建议的 25-羟维生素 D（25-OHD）目标值为 75-150nmol/L。我们在 2008 年发现只有 10%的胰腺功能不全（PI）儿童达到了这个目标。于是我们增加了补充剂的剂量，并在 2010 年进行了复查。
方法
我们纳入了在地区中心接受单一治疗的年龄≥1 岁的胰腺功能不全儿童。维生素 D3 的补充剂量增加了>450%，每日剂量分别为 3800IU 液体或 800IU 加 20000IU 每周片剂。2010 年也单独对胰腺功能正常（PS）儿童进行了审核。
结果
2008 年（n=78，10%>75nmol/L）时，儿童的 25-OHD 中位数水平为 51.5nmol/L，到 2010 年（n=72，51%>75nmol/L）时升高至 72nmol/L，p<0.0001。在 PS 儿童（n=15，2010 年）中，87%的儿童 25-OHD 水平<75nmol/L。
结论
补充剂的大量增加导致 25-OHD 水平显著升高，但仍有一半儿童未能达到推荐目标。
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