Chakrapani Andrea, Avery Anne, Warnke Roger
Department of Pathology, Oregon Health & Science University, Portland, OR 97239, USA.
Am J Dermatopathol. 2013 Apr;35(2):270-2. doi: 10.1097/DAD.0b013e3182624e98.
Primary cutaneous gamma delta T-cell lymphoma is a rare diagnosis with only 40 reported cases. We describe a case of cutaneous gamma delta T-cell lymphoma with hemophagocytic syndrome and brain involvement that was not apparent morphologically on skin biopsy and was diagnosed as perifolliculitis and lobular panniculitis. The biopsy was sent later for molecular studies to the University of Washington, which demonstrated a T-cell clone. This case demonstrates that a T-cell clone may be present in a skin biopsy without morphologic or immunophenotypic evidence of lymphoma.
原发性皮肤γδ T细胞淋巴瘤是一种罕见的诊断，仅有40例报告病例。我们描述了一例伴有噬血细胞综合征和脑受累的皮肤γδ T细胞淋巴瘤病例，该病例在皮肤活检时形态学上并不明显，最初被诊断为毛囊周炎和小叶性脂膜炎。活检样本后来被送往华盛顿大学进行分子研究，结果显示存在T细胞克隆。该病例表明，在皮肤活检中可能存在T细胞克隆，而无淋巴瘤的形态学或免疫表型证据。
