10-羟基喜树碱类似物的合成及初步抗癌活性评价。
Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs.
机构信息
Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy, Guangzhou 510632, China.
出版信息
Biol Pharm Bull. 2012;35(8):1295-9. doi: 10.1248/bpb.b12-00145.
PMID:22863928
Abstract
We have synthesized new 10-hydroxycamptothecin (HCPT) analogs and evaluated their anticancer activity in cell culture and in experimental animal tumor model. Although the new analogs were less potent against L1210 leukemia cells in vitro, some of them were more efficacious against L1210 leukemia in vivo compared to the parent HCPT.
摘要
我们合成了新的 10-羟基喜树碱（HCPT）类似物，并在细胞培养和实验动物肿瘤模型中评估了它们的抗癌活性。尽管新的类似物在体外对 L1210 白血病细胞的活性较低，但与母体 HCPT 相比，它们中的一些在体内对 L1210 白血病更有效。
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