Khalil Bassem, Aung KoKo, Mansi Ishak A
Union Memorial Hospital, Baltimore, MD, USA.
South Med J. 2012 Aug;105(8):411-5. doi: 10.1097/SMJ.0b013e318256ef1d.
Limited attention is directed to the potential conflicts of interest (COI) of the authors of practice guidelines writing groups of professional medical societies (PMS) and industry. The objective of this study was to report the proportion of authors with potential COI among guidelines writing groups of PMS.
A systematic search in PubMed to identify practice guidelines of a convenience sample of 12 publicly known PMS for a period of 3 years. The authors' disclosures of COI were reviewed for the identified guidelines.
We identified 126 guidelines, of which 107 (85%) reported authors' disclosures of COI and 19 (15%) did not. With the exception of the US Preventive Services Task Force, all of the reviewed guidelines writing groups of PMS had potential COI to some extent. The maximum percentage of authors with potential COI varied among PMS from 25% to 100%.
A substantial variation of percentage of authors with potential COI exists among guidelines writing groups of different PMS. Several practice guidelines of PMS fail to include the disclosures of potential COI in their published guidelines. We made several suggestions to promote the transparency of potential COI in clinical practice guidelines.
专业医学协会（PMS）和行业的实践指南编写组作者的潜在利益冲突（COI）受到的关注有限。本研究的目的是报告PMS指南编写组中存在潜在COI的作者比例。
在PubMed中进行系统检索，以确定12个知名PMS的便利样本在3年内的实践指南。对已识别指南中作者的COI披露情况进行审查。
我们识别出126项指南，其中107项（85%）报告了作者的COI披露情况，19项（15%）未报告。除美国预防服务工作组外，所有审查的PMS指南编写组都在一定程度上存在潜在COI。不同PMS中存在潜在COI的作者的最大比例从25%到100%不等。
不同PMS的指南编写组中存在潜在COI的作者比例存在很大差异。PMS的一些实践指南在其发布的指南中未包括潜在COI的披露。我们提出了一些建议以提高临床实践指南中潜在COI的透明度。
