Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Chem Commun (Camb). 2012 Sep 18;48(72):9092-4. doi: 10.1039/c2cc34725c. Epub 2012 Aug 3.
A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.
呈现了一种新型且汇聚的海兔素合成方法。以阴离子级联环合作为关键步骤，从 2'-氟苯乙酮出发，仅通过 6 步反应，以 45%的总收率即可得到该天然产物。该新方法还被扩展到海兔素一种新异构体的合成中。
