Plodek Alois, Bracher Franz
Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5-13, 81377 Munich, Germany.
Mar Drugs. 2016 Jan 26;14(2):26. doi: 10.3390/md14020026.
Secondary metabolites from marine organisms are a rich source of novel leads for drug development. Among these natural products, polycyclic aromatic alkaloids of the pyridoacridine type have attracted the highest attention as lead compounds for the development of novel anti-cancer and anti-infective drugs. Numerous sophisticated total syntheses of pyridoacridine alkaloids have been worked out, and many of them have also been extended to the synthesis of libraries of analogues of the alkaloids. This review summarizes the progress in the chemistry of pyridoacridine alkaloids that was made in the last one-and-a-half decades.
海洋生物中的次生代谢产物是药物开发新先导化合物的丰富来源。在这些天然产物中,吡啶并吖啶型多环芳烃生物碱作为新型抗癌和抗感染药物开发的先导化合物受到了最高度的关注。已经完成了许多复杂的吡啶并吖啶生物碱全合成,其中许多还扩展到了生物碱类似物库的合成。本综述总结了过去十五年中吡啶并吖啶生物碱化学的进展。