Bhatawdekar A M, Kumta N B, Dave K H, Bharucha B A
Department of Pediatrics, Seth GS Medical College and KEM Hospital, Parel, Bombay.
Indian Pediatr. 1990 Sep;27(9):911-4.
A study was carried out to test the efficacy of oral polio immunization commencing in the newborn period. In Group A, 47 term newborn infants were given trivalent oral polio vaccine (TOPV) within the first four days, at one month and at two months. In Group B, 21 infants were given TOPV at 3, 4 and 5 months. The seroconversion rates for types 1, 2 and 3 were 87.2, 95.7 and 72.3%, respectively in Group A and 85.7, 95.2 and 66.7%, respectively in Group B after 3 doses of TOPV, the differences being insignificant. Oral polio immunization beginning in the newborn period was as effective as when commenced at 3 months of age. Before immunization, the number of babies with protective titers against polioviruses were significantly more in Group A as compared to Group B. Thus, the later onset of immunization schedule leaves more children susceptible to poliomyelitis during the first 3 months of life.
开展了一项研究，以测试从新生儿期开始口服脊髓灰质炎疫苗的效果。A组47名足月儿在出生后前四天、一个月和两个月时服用三价口服脊髓灰质炎疫苗（TOPV）。B组21名婴儿在3、4和5个月时服用TOPV。A组在3剂TOPV接种后1型、2型和3型的血清转化率分别为87.2%、95.7%和72.3%，B组分别为85.7%、95.2%和66.7%，差异不显著。从新生儿期开始口服脊髓灰质炎疫苗与3个月大时开始接种同样有效。免疫前，A组中对脊髓灰质炎病毒具有保护性滴度的婴儿数量明显多于B组。因此，免疫计划开始时间较晚使更多儿童在生命的前3个月易患脊髓灰质炎。
