Weckx L Y, Schmidt B J, Herrmann A A, Miyasaki C H, Novo N F
Escola Paulista de Medicina, São Paulo, Brazil.
Bull World Health Organ. 1992;70(1):85-91.
Described is the evaluation in Brazil of the immune response of early immunization with trivalent oral poliovirus vaccine (TOPV). A total of 85 normal neonates from São Paulo were assigned one of the following immunization schedules: group A--one dose of TOPV at birth and subsequent doses at 2, 4, and 9 months of age; or group B--one dose of TOPV at 2, 4 and 6 months of age. Blood samples were collected sequentially from the mother at delivery, from the umbilical cord, and from the child at 2, 4, 6, 9 and 12 months of age for assay of poliovirus neutralizing antibodies. Administration of TOPV at birth, in addition to establishing immunity against poliomyelitis at an earlier stage, produced a superior immune response to poliovirus type 3. At the end of the first year, the proportion of susceptible individuals was 3.7% in group A and 25.9% in group B. When immunization against poliomyelitis is started at birth, excellent seroconversion rates are obtained from the third dose onward.
本文描述了在巴西对三价口服脊髓灰质炎疫苗（TOPV）早期免疫的免疫反应进行的评估。来自圣保罗的85名正常新生儿被分配到以下免疫接种方案之一：A组——出生时接种一剂TOPV，随后在2、4和9月龄接种后续剂量；或B组——在2、4和6月龄接种一剂TOPV。在分娩时从母亲、脐带以及在儿童2、4、6、9和12月龄时依次采集血样，用于检测脊髓灰质炎病毒中和抗体。出生时接种TOPV，除了能在更早阶段建立针对脊髓灰质炎的免疫力外，还能对3型脊髓灰质炎病毒产生更强的免疫反应。在第一年末，A组易感个体的比例为3.7%，B组为25.9%。当从出生开始接种脊髓灰质炎疫苗时，从第三剂起可获得优异的血清转化率。
