Agarwal A, Sharma D, Kumari S, Khare S
Department of Pediatrics, Lady Hardinge Medical College, New Delhi.
Indian Pediatr. 1991 Oct;28(10):1141-5.
The study was undertaken to compare the antibody response of 6-12 weeks old infants after three doses of standard trivalent oral polio vaccine (TOPV) (Groups A; (n = 42) with three doses of double the amount of TOPV (Group B; n = 35). Seroconversions in Group A were 64.2, 80.9% and 57.1% for Types I, II and III polioviruses, respectively. The corresponding figures for Group B were 77.7, 80.0 and 60.6%, respectively, the differences being insignificant. Differences in feeding practices and presence of maternal antibodies did not affect seroconversion. This suggests that increasing the amount of vaccine virus in each dose is not an alternative to present strategy. Breast feeding and presence of maternal antibodies are not responsible for poor seroconversion.
开展该研究是为了比较6至12周龄婴儿在接种三剂标准三价口服脊髓灰质炎疫苗（TOPV）后（A组；n = 42）与接种三剂双倍剂量TOPV后（B组；n = 35）的抗体反应。A组中I型、II型和III型脊髓灰质炎病毒的血清转化率分别为64.2%、80.9%和57.1%。B组的相应数字分别为77.7%、80.0%和60.6%，差异不显著。喂养方式的差异和母体抗体的存在并不影响血清转化。这表明增加每剂疫苗病毒的量并非当前策略的替代方案。母乳喂养和母体抗体的存在并非血清转化不佳的原因。
