Ali Rola H, Lee Cheng-Han, Hayes Malcolm M
Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada.
Diagn Cytopathol. 2014 Feb;42(2):161-4. doi: 10.1002/dc.22894. Epub 2012 Aug 4.
We report the fine-needle aspiration cytology of a case of metastatic small cell osteosarcoma to the liver with rosette formation, originating from distal femur, in a 36-year-old female. The aspirate of the liver metastases revealed a relatively monomorphic population of mitotically active small blue round cells arranged in clusters with prominent rosette formation simulating a neuroendocrine carcinoma or other rosette-forming small round cell tumors such as Ewing sarcoma. No extracellular mineralized matrix material was present. Comparison of the liver aspirate with the biopsy from the distal femoral lesion was crucial in reaching the correct diagnosis of metastatic small cell osteosarcoma with rosette formation. This is a potential diagnostic pitfall, particularly if interpreted without the knowledge of a suspected primary bone tumor.
我们报告了一例36岁女性的转移性小细胞骨肉瘤细针穿刺细胞学检查，该肿瘤转移至肝脏并形成菊形团，原发于股骨远端。肝脏转移灶的抽吸物显示出一群相对单一形态的有丝分裂活跃的小蓝色圆形细胞，这些细胞聚集成簇，有明显的菊形团形成，类似神经内分泌癌或其他形成菊形团的小圆形细胞肿瘤，如尤因肉瘤。抽吸物中未发现细胞外矿化基质物质。将肝脏抽吸物与股骨远端病变的活检组织进行比较，对于正确诊断伴有菊形团形成的转移性小细胞骨肉瘤至关重要。这是一个潜在的诊断陷阱，尤其是在不了解疑似原发性骨肿瘤的情况下进行解读时。
