Bucan Vesna, Choi Claudia Y U, Lazaridis Andrea, Vogt Peter M, Reimers Kerstin
Department of Plastic, Hand and Reconstructive Surgery, Medical School Hanover, D-30659 Hanover, Germany.
Oncol Lett. 2011 May;2(3):419-422. doi: 10.3892/ol.2011.285. Epub 2011 Mar 21.
Lifeguard (LFG), an anti-apoptotic protein with high expression rates in breast cancer cells, has been identified as a molecule that inhibits death mediated by Fas. The molecular function of LFG and its regulation in the carcinogenesis of human breast and sarcoma cells, however, remains to be elucidated. In the present study, we investigated the ability of LFG expression to inhibit apoptosis induced by the alkyl-phospholipid perifosine. Results showed that LFG was able to be downregulated in selected sarcoma and breast cancer cell lines characterized by high endogenous LFG expression. A decreased LFG expression led to enhanced sensitivity to treatment with an agonistic Fas antibody or treatment with perifosine. Taken together, our findings indicate the role of LFG as an anti-apoptotic protein and provide further evidence of the potential of LFG as a target for the development of novel therapeutic strategies.
救生员（LFG）是一种在乳腺癌细胞中高表达的抗凋亡蛋白，已被鉴定为一种抑制Fas介导的细胞死亡的分子。然而，LFG的分子功能及其在人乳腺癌和肉瘤细胞致癌过程中的调控仍有待阐明。在本研究中，我们研究了LFG表达抑制烷基磷脂哌立福新诱导的细胞凋亡的能力。结果表明，在以高内源性LFG表达为特征的选定肉瘤和乳腺癌细胞系中，LFG能够被下调。LFG表达的降低导致对激动性Fas抗体治疗或哌立福新治疗的敏感性增强。综上所述，我们的研究结果表明LFG作为一种抗凋亡蛋白的作用，并进一步证明了LFG作为新型治疗策略开发靶点的潜力。
