Hopfgartner Gérard, Varesio Emmanuel
School of Pharmaceutical Sciences University of Geneva, University of Lausanne Life Sciences Mass Spectrometry Quai Ernest-Ansermet, 30 CH-1211 Geneva 4, Switzerland.
Chimia (Aarau). 2012;66(5):335-8. doi: 10.2533/chimia.2012.335.
The Life Sciences Mass Spectrometry (LSMS) research unit focuses on the development of novel analytical workflows based on innovative mass spectrometric and software tools for the analysis of low molecular weight compounds, peptides and proteins in complex biological matrices. The present article summarizes some of the recent work of the unit: i) the application of matrix-assisted laser desorption/ionization (MALDI) for mass spectrometry imaging (MSI) of drug of abuse in hair, ii) the use of high resolution mass spectrometry for simultaneous qualitative/quantitative analysis in drug metabolism and metabolomics, and iii) the absolute quantitation of proteins by mass spectrometry using the selected reaction monitoring mode.
生命科学质谱（LSMS）研究小组专注于基于创新的质谱和软件工具开发新型分析工作流程，用于分析复杂生物基质中的低分子量化合物、肽和蛋白质。本文总结了该小组最近的一些工作：i）基质辅助激光解吸/电离（MALDI）在毛发中滥用药物质谱成像（MSI）中的应用；ii）高分辨率质谱在药物代谢和代谢组学中同时进行定性/定量分析的应用；iii）使用选择反应监测模式通过质谱对蛋白质进行绝对定量。
