Institut Charles Gerhardt de Montpellier, ICGM-MACS, UMR 5253 CNRS-ENSCM-UM2-UM1, 8 rue de l'Ecole Normale, 34296 Montpellier cedex 5, France.
Phys Chem Chem Phys. 2012 Sep 21;14(35):12285-94. doi: 10.1039/c2cp42092a. Epub 2012 Aug 7.
Silica microspheres encapsulating ibuprofen in separated domains at the nanometre scale are formed by spray-drying and sol-gel processes. A detailed (1)H and (13)C NMR study of these microspheres shows that ibuprofen molecules are mobile and are interacting through hydrogen bonds with other ibuprofen molecules. (1)H magnetisation exchange NMR experiments were employed to characterize the size of the ibuprofen domains at the nanometre scale. These domains are solely formed by ibuprofen, and their diameters are estimated to be ∼40 nm in agreement with TEM observations. The nature and formation of these particular texture and drug dispersion are discussed.
通过喷雾干燥和溶胶-凝胶工艺形成了在纳米尺度上分离的域内包埋布洛芬的二氧化硅微球。对这些微球的详细的 (1)H 和 (13)C NMR 研究表明，布洛芬分子是可移动的，并通过氢键与其他布洛芬分子相互作用。采用 (1)H 磁化交换 NMR 实验来表征纳米尺度上布洛芬域的大小。这些域仅由布洛芬形成，其直径估计为 ∼40nm，与 TEM 观察结果一致。讨论了这种特殊纹理和药物分散的性质和形成。
