Ultrasound Unit, Department of Obstetrics and Gynecology, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.
Fetal Diagn Ther. 2012;32(4):271-6. doi: 10.1159/000339413. Epub 2012 Aug 1.
To update the reference ranges for the ductus venosus pulsatility index (DVPI) at 11+0 to 13+6 gestational weeks.
DVPI was calculated in 14,444 singleton fetuses at 11+0 to 13+6 weeks in two Fetal Medicine Centers, during a 4-year period. Using previously described medians, DVPI evolution was assessed both over the study period on a yearly basis and over gestation, grouping fetuses according to 5-mm crown-rump length (CRL) ranges. Weighted DVPI medians, the 5th and 95th percentiles and distribution parameters for unaffected and trisomy 21 fetuses were newly calculated.
A significant DVPI multiple of the median decrease was observed over both the study period (p < 0.01) and over gestation (p < 0.01) using previous medians, in the two centers. Newly calculated weighted medians were lower than those previously described, decreasing with CRL. Distribution parameters calculated using the new medians were different from those previously described.
DVPI reference ranges were lower than those previously reported and decreased with CRL. Updated medians and distribution parameters should be considered to include the DVPI as a Gaussian marker in trisomy 21 screening and for quality control purposes.
更新 11+0 至 13+6 孕周静脉导管搏动指数（DVPI）的参考范围。
在两个胎儿医学中心，对 14444 例 11+0 至 13+6 孕周的单胎胎儿进行了 DVPI 计算。在 4 年的研究期间，使用之前描述的中位数，按每年和整个妊娠进行评估 DVPI 的演变，并根据 5mm 头臀长（CRL）范围将胎儿分组。新计算了未受影响和 21 三体胎儿的加权 DVPI 中位数、第 5 百分位数和第 95 百分位数以及分布参数。
在两个中心，使用以前的中位数，在整个研究期间（p < 0.01）和整个妊娠期间（p < 0.01）均观察到显著的 DVPI 中位数倍数下降。新计算的加权中位数低于之前描述的中位数，且随 CRL 降低而降低。使用新中位数计算的分布参数与之前描述的不同。
DVPI 参考范围低于之前报道的范围，且随 CRL 降低而降低。应考虑更新中位数和分布参数，以便将 DVPI 作为 21 三体筛查和质量控制的高斯标志物纳入。
