Pediatric Ambulatory Community Clinic, Petach Tikva, Israel.
Pediatrics. 2012 Sep;130(3):465-71. doi: 10.1542/peds.2011-3075. Epub 2012 Aug 6.
To compare the effects of a single nocturnal dose of 3 honey products (eucalyptus honey, citrus honey, or labiatae honey) to placebo (silan date extract) on nocturnal cough and difficulty sleeping associated with childhood upper respiratory tract infections (URIs).
A survey was administered to parents on 2 consecutive days, first on the day of presentation, when no medication had been given the previous evening, and the following day, when the study preparation was given before bedtime, based on a double-blind randomization plan. Participants included 300 children aged 1 to 5 years with URIs, nocturnal cough, and illness duration of ≤ 7 days from 6 general pediatric community clinics. Eligible children received a single dose of 10 g of eucalyptus honey, citrus honey, labiatae honey, or placebo administered 30 minutes before bedtime. Main outcome measures were cough frequency, cough severity, bothersome nature of cough, and child and parent sleep quality.
In all 3 honey products and the placebo group, there was a significant improvement from the night before treatment to the night of treatment. However, the improvement was greater in the honey groups for all the
Parents rated the honey products higher than the silan date extract for symptomatic relief of their children's nocturnal cough and sleep difficulty due to URI. Honey may be a preferable treatment for cough and sleep difficulty associated with childhood URI.
比较单剂量夜间服用 3 种蜂蜜制品(桉树蜂蜜、柑橘蜂蜜或唇形科蜂蜜)与安慰剂(硅兰枣提取物)对儿童上呼吸道感染(URI)相关夜间咳嗽和睡眠困难的影响。
连续 2 天对父母进行调查,第一天是在没有给予前一天晚上药物的就诊当天,第二天是在根据双盲随机分组方案在睡前给予研究准备时。参与者包括 300 名年龄在 1 至 5 岁之间的患有 URI、夜间咳嗽和疾病持续时间≤7 天的儿童,来自 6 家普通儿科社区诊所。符合条件的儿童在睡前 30 分钟接受 10 克桉树蜂蜜、柑橘蜂蜜、唇形科蜂蜜或安慰剂的单剂量治疗。主要结局指标是咳嗽频率、咳嗽严重程度、咳嗽的困扰程度以及儿童和父母的睡眠质量。
在所有 3 种蜂蜜制品和安慰剂组中,与治疗前一天晚上相比,治疗当晚均有显著改善。然而,蜂蜜组的改善更为明显。
父母对蜂蜜制品的评价高于硅兰枣提取物,认为其可更有效地缓解儿童因 URI 导致的夜间咳嗽和睡眠困难。蜂蜜可能是治疗儿童 URI 相关咳嗽和睡眠困难的更优选择。