二乙酰氨己酸在骨关节炎病程中分子水平的作用。
Effects of diacerein at the molecular level in the osteoarthritis disease process.
机构信息
Arthritis Centre, University of Montreal, Head, Arthritis Division (CHUM), Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, Canada.
出版信息
Ther Adv Musculoskelet Dis. 2010 Apr;2(2):95-104. doi: 10.1177/1759720X09359104.
Abstract
In osteoarthritis (OA), the alterations in joint tissues are numerous and involve morphological, biochemical and metabolic changes and an upregulation of the inflammatory pathways. The focus of this article is a brief narrative review of the effects of diacerein, an antirheumatic drug from the anthraquinone chemical class, and its active metabolite, rhein, on the factors that participate in the complex interaction between OA tissues and cells leading to the progression of joint structural changes.
摘要
在骨关节炎（OA）中，关节组织的改变很多，涉及形态、生化和代谢变化以及炎症途径的上调。本文的重点是简要叙述二乙酰氨己酸（一种来自蒽醌类化学物质的抗风湿药物）及其活性代谢产物大黄酸对参与 OA 组织和细胞之间复杂相互作用从而导致关节结构变化进展的因素的影响。
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Arthritis Rheum. 2009 May;60(5):1438-50. doi: 10.1002/art.24489.
2
Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis.双醋瑞因的代谢产物大黄酸可降低骨关节炎软骨细胞和滑膜细胞的增殖，且不诱导细胞凋亡。
Scand J Rheumatol. 2009 Mar-Apr;38(2):104-11. doi: 10.1080/03009740802421996.
3
A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI.一种利用磁共振成像（MRI）评估膝骨关节炎患者滑膜炎严重程度与症状及软骨体积丢失相关性的新的非侵入性方法。
Osteoarthritis Cartilage. 2008;16 Suppl 3:S8-13. doi: 10.1016/j.joca.2008.06.007. Epub 2008 Jul 30.
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9
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