Department of Public Health, Medical College of Soochow university, SuZhou, JiangSu 215123, China.
Int J Cardiol. 2013 Sep 10;167(6):2781-5. doi: 10.1016/j.ijcard.2012.07.003. Epub 2012 Aug 5.
Few prospective studies on association between waist circumference and hypertension have taken account of the dynamic change of WC, which caused by lifestyle modification.
After a baseline investigation, we conducted the first and the second follow-up assessments for subjects after 2 and 5 years, respectively. The difference value (D-value, the value at the first follow-up minus the value at baseline) in WC was calculated to evaluate 2 years change of WC. The association between 2 years change of WC and incident hypertension was analyzed by using Cox proportional hazards regression model.
Among 2778 participants free of hypertension at baseline and the first follow-up, 660 (23.8%) subjects developed hypertension over a period of 5 years (between the first and the second follow-up assessments). In both genders, the incidence density and HRs of hypertension were all increased with WC D-value regardless of their abdominal obesity status at baseline. Compared with participants who were non-abdominal obese both at baseline and first follow up, hypertension risk was higher in subjects who were abdominal obese both at baseline and the first follow-up, and in subjects who were non-abdominal obese at baseline but with abdominal obesity at the first follow up.
WC dynamic change was associated with incident hypertension, and more WC reduction was associated with more hypertension risk decrease.
很少有前瞻性研究考虑到生活方式改变引起的腰围动态变化与高血压之间的关系。
在基线调查后，我们分别在 2 年和 5 年后对受试者进行了第一次和第二次随访评估。计算 WC 的差值（D 值，第一次随访时的值减去基线时的值）以评估 WC 的 2 年变化。使用 Cox 比例风险回归模型分析 WC 2 年变化与新发高血压之间的关系。
在基线和第一次随访时无高血压的 2778 名参与者中，有 660 名（23.8%）在 5 年内发生高血压（在第一次和第二次随访评估之间）。在男性和女性中，无论基线时是否存在腹型肥胖，WC D 值与高血压的发生率密度和 HR 均呈正相关。与基线和第一次随访时均非腹型肥胖的参与者相比，基线和第一次随访时均为腹型肥胖的参与者以及基线时非腹型肥胖但第一次随访时为腹型肥胖的参与者发生高血压的风险更高。
WC 的动态变化与新发高血压有关，WC 减少越多，高血压风险降低越多。
