University Vita-Salute San Raffaele, Milan, Italy.
Psychiatry Res. 2012 Jul 30;203(1):61-6. doi: 10.1016/j.pscychresns.2011.09.010. Epub 2012 Aug 4.
Borderline personality disorder (BPD) is a severe clinical condition characterised by different maladaptive traits such as impulsivity and affective lability. Mood and emotion dysregulation are core features of affective disorders. Indeed patients affected by mood disorder (MD) have a significantly higher prevalence of comorbid BPD, resulting in more unstable mood and poorer response to medication. Blood oxygen level-dependent functional magnetic resonance imaging has been used to investigate the neural correlates of emotional face processing. Images for each subject were entered into an analysis of variance (ANOVA) dividing participants into three group (MD, MD+BPD, Controls). MD+BPD patients show lower activations in the dorsolateral prefrontal cortex and higher activations in the cingulate cortex and hippocampus. The present study identifies the neural basis of the interaction between BPD and MD. The lower rate of response to treatment in MD+BPD could be related to a more severe emotional dysregulation syndrome.
边缘型人格障碍（BPD）是一种严重的临床病症，其特征是存在冲动和情感不稳定等不同的适应不良特征。情绪和情感调节障碍是情感障碍的核心特征。事实上，患有心境障碍（MD）的患者合并边缘型人格障碍的患病率明显更高，导致情绪更不稳定，对药物治疗的反应更差。血氧水平依赖功能磁共振成像已被用于研究情绪面孔处理的神经相关性。将每个受试者的图像输入方差分析（ANOVA），将参与者分为三组（MD、MD+BPD 和对照组）。MD+BPD 患者的背外侧前额叶皮层激活较低，而扣带回皮层和海马体的激活较高。本研究确定了 BPD 和 MD 之间相互作用的神经基础。MD+BPD 患者治疗反应率较低可能与更严重的情绪失调综合征有关。
