State Key Laboratory of Bioreactor Engineering & Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, China.
Chem Commun (Camb). 2012 Oct 7;48(77):9574-6. doi: 10.1039/c2cc34632j.
We present a nanoplasmonic aptasensor for adenosine triphosphate (ATP) by using single gold nanoparticles (GNPs) as probes. The specific aptamer-ATP binding induced conformational change could modulate the surface-dependent self-catalytic growth of GNPs, which enabled the detection of ATP with ultra-sensitivity and selectivity.
我们提出了一种基于单金纳米粒子（GNPs）作为探针的纳米等离子体适体传感器来检测三磷酸腺苷（ATP）。特定的适体-ATP 结合诱导的构象变化可以调节依赖于表面的 GNPs 自催化生长，从而实现了对 ATP 的超灵敏和选择性检测。
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