Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.
Clin Pharmacol Ther. 2012 Sep;92(3):340-8. doi: 10.1038/clpt.2012.110. Epub 2012 Aug 8.
Nuclear erythroid 2-related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease. Here, we focus on the most common liver diseases-nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease, and drug-induced liver injury-and highlight areas in the development of these conditions where activation of Nrf2 may alleviate disease progression.
核红细胞 2 相关因子 2（Nrf2）是一种氧化应激介导的转录因子，具有多种下游靶标，旨在实现细胞保护。Nrf2 最近被认为是治疗肝脏疾病的新的治疗靶点。在这里，我们重点关注最常见的肝脏疾病——非酒精性脂肪性肝病/肝炎、酒精性肝病和药物性肝损伤，并强调在这些疾病的发展过程中，激活 Nrf2 可能会缓解疾病进展的领域。
