天然存在的Nrf2激活剂：在肝损伤治疗中的潜力。
Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury.
作者信息
Jadeja Ravirajsinh N, Upadhyay Kapil K, Devkar Ranjitsinh V, Khurana Sandeep
机构信息
Digestive Health Center, Medical College of Georgia, Augusta, GA 30912, USA.
Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India.
出版信息
Oxid Med Cell Longev. 2016;2016:3453926. doi: 10.1155/2016/3453926. Epub 2016 Dec 22.
Abstract
Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative stress frequently triggers antioxidant response by activating nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor, which upregulates various cytoprotective genes. Thus, Nrf2 is considered a potential therapeutic target to halt liver injury. Several studies indicate that activation of Nrf2 signaling pathway ameliorates liver injury. The hepatoprotective potential of naturally occurring compounds has been investigated in various models of liver injuries. In this review, we comprehensively appraise various phytochemicals that have been assessed for their potential to halt acute and chronic liver injury by enhancing the activation of Nrf2 and have the potential for use in humans.
摘要
氧化应激在急性和慢性肝损伤中起主要作用。在肝细胞中，氧化应激经常通过激活核红细胞2相关因子2（Nrf2）（一种转录因子）来触发抗氧化反应，该转录因子上调各种细胞保护基因。因此，Nrf2被认为是阻止肝损伤的潜在治疗靶点。多项研究表明，Nrf2信号通路的激活可改善肝损伤。天然化合物的肝保护潜力已在各种肝损伤模型中进行了研究。在这篇综述中，我们全面评估了各种植物化学物质，这些物质已被评估具有通过增强Nrf2的激活来阻止急性和慢性肝损伤的潜力，并且有可能用于人类。
相似文献
1
Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury.天然存在的Nrf2激活剂：在肝损伤治疗中的潜力。
Oxid Med Cell Longev. 2016;2016:3453926. doi: 10.1155/2016/3453926. Epub 2016 Dec 22.
2
Oxyresveratrol abrogates oxidative stress by activating ERK-Nrf2 pathway in the liver.氧化白藜芦醇通过激活肝脏中的 ERK-Nrf2 通路来消除氧化应激。
Chem Biol Interact. 2016 Feb 5;245:110-21. doi: 10.1016/j.cbi.2015.06.024. Epub 2015 Jun 20.
3
Epimedium koreanum Ameliorates Oxidative Stress-Mediated Liver Injury by Activating Nuclear Factor Erythroid 2-Related Factor 2.朝藿定通过激活核因子红细胞 2 相关因子 2 改善氧化应激介导的肝损伤。
Am J Chin Med. 2018;46(2):469-488. doi: 10.1142/S0192415X18500246. Epub 2018 Feb 12.
4
Dendrobium nobile Lindl. alkaloids-mediated protection against CClinduced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway.铁皮石斛生物碱通过激活 Nrf2 信号通路介导对抗 CCl4 诱导的肝线粒体氧化损伤的保护作用。
Biomed Pharmacother. 2020 Sep;129:110351. doi: 10.1016/j.biopha.2020.110351. Epub 2020 Jun 11.
5
Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression.伞形花内酯和瑞香素通过核因子红细胞2相关因子2介导的血红素加氧酶-1表达减轻四氯化碳诱导的大鼠肝毒性。
Environ Toxicol Pharmacol. 2014 Sep;38(2):531-41. doi: 10.1016/j.etap.2014.08.004. Epub 2014 Aug 13.
6
Activation of the Nrf2 Signaling Pathway Involving KLF9 Plays a Critical Role in Allicin Resisting Against Arsenic Trioxide-Induced Hepatotoxicity in Rats.涉及KLF9的Nrf2信号通路激活在大蒜素抵抗大鼠三氧化二砷诱导的肝毒性中起关键作用。
Biol Trace Elem Res. 2017 Mar;176(1):192-200. doi: 10.1007/s12011-016-0821-1. Epub 2016 Aug 25.
7
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.新橘皮苷二氢查尔酮通过不同机制对抗 CCl₄ 诱导的肝损伤：自由基清除和 Nrf2 激活的作用。
J Agric Food Chem. 2015 Jun 10;63(22):5468-75. doi: 10.1021/acs.jafc.5b01750. Epub 2015 May 28.
8
Nrf2 protects against diquat-induced liver and lung injury.Nrf2 可预防百草枯诱导的肝肺损伤。
Free Radic Res. 2012 Oct;46(10):1220-9. doi: 10.3109/10715762.2012.700709. Epub 2012 Jul 11.
9
Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism.槲皮素对四氯化碳诱导的小鼠急性肝损伤的治疗性解毒作用及其机制
J Zhejiang Univ Sci B. 2014 Dec;15(12):1039-47. doi: 10.1631/jzus.B1400104.
10
Advances of natural activators for Nrf2 signaling pathway on cholestatic liver injury protection: a review.天然 Nrf2 信号通路激活剂在胆汁淤积性肝损伤保护中的研究进展：综述。
Eur J Pharmacol. 2021 Nov 5;910:174447. doi: 10.1016/j.ejphar.2021.174447. Epub 2021 Aug 27.
引用本文的文献
1
The protective effect of Saudi Arabian bee honey against excessive weight gain and obesity-related parameters in rats fed a high-fat diet.沙特阿拉伯蜂蜂蜜对高脂饮食喂养大鼠体重过度增加及肥胖相关参数的保护作用。
Front Nutr. 2025 Aug 18;12:1582408. doi: 10.3389/fnut.2025.1582408. eCollection 2025.
2
Keap1 Deletion Rescues Cell Death Associated With Gpx4 Loss in Hepatocytes During Acute Liver Injury.在急性肝损伤期间，Keap1缺失可挽救与肝细胞中Gpx4缺失相关的细胞死亡。
Liver Int. 2025 Sep;45(9):e70210. doi: 10.1111/liv.70210.
3
Impact of Curcumin on Frozen Bovine Sperm Quality and In Vitro Bovine Oocyte Maturation.姜黄素对冷冻牛精子质量及体外牛卵母细胞成熟的影响
Vet Sci. 2025 May 5;12(5):441. doi: 10.3390/vetsci12050441.
4
Thermal Ageing of Black Garlic Enhances Cellular Antioxidant Potential Through the Activation of the Nrf2-Mediated Pathway.黑蒜的热老化通过激活Nrf2介导的途径增强细胞抗氧化潜力。
Food Technol Biotechnol. 2025 Mar;63(1):36-45. doi: 10.17113/ftb.63.01.25.8474.
5
Emodin Improves Juvenile Largemouth Bass () Liver Health Through Nrf2/NF-κB Pathway and Fat Metabolism: Growth Performance, Immune Response and Resistance Against Infection.大黄素通过Nrf2/NF-κB途径和脂肪代谢改善幼鱼大口黑鲈肝脏健康：生长性能、免疫反应和抗感染能力
Animals (Basel). 2025 Jan 10;15(2):178. doi: 10.3390/ani15020178.
6
Oroxylin A suppressed colorectal cancer metastasis by inhibiting the activation of the TGF-β/SMAD signal pathway.山奈素通过抑制 TGF-β/SMAD 信号通路的激活抑制结直肠癌转移。
Sci Rep. 2024 Oct 15;14(1):24091. doi: 10.1038/s41598-024-75457-3.
7
L. (Safflower) Flower Extract Attenuates Hepatic Injury and Steatosis in a Rat Model of Type 2 Diabetes Mellitus via Nrf2-Dependent Hypoglycemic, Antioxidant, and Hypolipidemic Effects.L.（红花）花提取物通过依赖Nrf2的降血糖、抗氧化和降血脂作用减轻2型糖尿病大鼠模型的肝损伤和脂肪变性。
Antioxidants (Basel). 2024 Sep 10;13(9):1098. doi: 10.3390/antiox13091098.
8
Huaier relieves oxaliplatin-induced hepatotoxicity through activation of the PI3K/AKT/Nrf2 signaling pathway in C57BL/6 mice.华蟾素通过激活C57BL/6小鼠的PI3K/AKT/Nrf2信号通路减轻奥沙利铂诱导的肝毒性。
Heliyon. 2024 Aug 29;10(17):e37010. doi: 10.1016/j.heliyon.2024.e37010. eCollection 2024 Sep 15.
9
NKU FL1-8 Isolated from Infant Feces Ameliorates the Alcoholic Liver Damage by Regulating the Gut Microbiota and Intestinal Barrier in C57BL/6J Mice.从婴儿粪便中分离出的 NKU FL1-8 通过调节肠道微生物群和肠道屏障改善 C57BL/6J 小鼠的酒精性肝损伤。
Nutrients. 2024 Jul 4;16(13):2139. doi: 10.3390/nu16132139.
10
Plumbagin ameliorates LPS-induced acute lung injury by regulating PI3K/AKT/mTOR and Keap1-Nrf2/HO-1 signalling pathways.白花丹素通过调节 PI3K/AKT/mTOR 和 Keap1-Nrf2/HO-1 信号通路改善 LPS 诱导的急性肺损伤。
J Cell Mol Med. 2024 Jul;28(13):e18386. doi: 10.1111/jcmm.18386.
本文引用的文献
1
Herbal Hepatotoxicity: Clinical Characteristics and Listing Compilation.草药肝毒性：临床特征与列表汇编
Int J Mol Sci. 2016 Apr 27;17(5):588. doi: 10.3390/ijms17050588.
2
Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation.芒果苷通过激活Nrf2信号通路和抑制NLRP3炎性小体激活减轻脂多糖和D-半乳糖胺诱导的急性肝损伤。
Eur J Pharmacol. 2016 Jan 5;770:85-91. doi: 10.1016/j.ejphar.2015.12.006. Epub 2015 Dec 5.
3
Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway.天麻素通过AMPK/Nrf2通路改善非酒精性脂肪性肝病中的氧化应激和促炎反应。
Phytother Res. 2016 Mar;30(3):402-11. doi: 10.1002/ptr.5541. Epub 2015 Dec 4.
4
Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases.Nrf2-ARE 通路：一种针对神经退行性疾病中氧化应激和神经炎症的新兴靶点。
Pharmacol Ther. 2016 Jan;157:84-104. doi: 10.1016/j.pharmthera.2015.11.003. Epub 2015 Nov 23.
5
Nrf2 in health and disease: current and future clinical implications.Nrf2在健康与疾病中的作用：当前及未来的临床意义
Clin Sci (Lond). 2015 Dec;129(12):989-99. doi: 10.1042/CS20150436.
6
Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism.齐墩果酸可减轻胆管结扎小鼠的梗阻性胆汁淤积，可能是通过激活NRF2-MRPs和拮抗FXR来实现的。
Eur J Pharmacol. 2015 Oct 15;765:131-9. doi: 10.1016/j.ejphar.2015.08.029. Epub 2015 Aug 20.
7
Metabolic Syndrome: Nonalcoholic Fatty Liver Disease.代谢综合征：非酒精性脂肪性肝病
FP Essent. 2015 Aug;435:24-9.
8
Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats.芍药苷通过PI3K/Akt依赖性途径激活Nrf2改善ANIT诱导的大鼠胆汁淤积。
Phytother Res. 2015 Nov;29(11):1768-75. doi: 10.1002/ptr.5431. Epub 2015 Aug 13.
9
Antioxidant responses and cellular adjustments to oxidative stress.抗氧化反应及细胞对氧化应激的调节
Redox Biol. 2015 Dec;6:183-197. doi: 10.1016/j.redox.2015.07.008. Epub 2015 Jul 21.
10
Withaferin-A Reduces Acetaminophen-Induced Liver Injury in Mice.非洲铁海棠素A减轻对乙酰氨基酚诱导的小鼠肝损伤。
Biochem Pharmacol. 2015 Sep 1;97(1):122-32. doi: 10.1016/j.bcp.2015.07.024. Epub 2015 Jul 23.
Zotero 插件