Laboratory of Molecular Biology, Wageningen University, 6708PB Wageningen, The Netherlands.
Development. 2012 Sep;139(17):3081-98. doi: 10.1242/dev.074674.
Members of the MADS-box transcription factor family play essential roles in almost every developmental process in plants. Many MADS-box genes have conserved functions across the flowering plants, but some have acquired novel functions in specific species during evolution. The analyses of MADS-domain protein interactions and target genes have provided new insights into their molecular functions. Here, we review recent findings on MADS-box gene functions in Arabidopsis and discuss the evolutionary history and functional diversification of this gene family in plants. We also discuss possible mechanisms of action of MADS-domain proteins based on their interactions with chromatin-associated factors and other transcriptional regulators.
MADS 盒转录因子家族的成员在植物的几乎每一个发育过程中都起着至关重要的作用。许多 MADS 盒基因在开花植物中具有保守的功能，但在进化过程中，一些基因在特定物种中获得了新的功能。对 MADS 结构域蛋白相互作用和靶基因的分析为其分子功能提供了新的见解。在这里，我们回顾了拟南芥中 MADS 盒基因功能的最新发现，并讨论了该基因家族在植物中的进化历史和功能多样化。我们还根据 MADS 结构域蛋白与染色质相关因子和其他转录因子的相互作用，讨论了 MADS 结构域蛋白的可能作用机制。
