Unité de Prévention Cardiovasculaire, Pole Cardiologie Métabolisme, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 83, Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.
Curr Atheroscler Rep. 2012 Oct;14(5):429-37. doi: 10.1007/s11883-012-0264-x.
18F-FDG PET is a new noninvasive tool for inflammation functional imaging. Low spatial resolution is now compensated by coregistration with CT or MRI. New mechanistic insights have emerged from animal and histology to explain the obtained signals by hypoxia, macrophage infiltration, and differentiation. Mixed results have been found in biomarkers studies. Interesting data have come recently linking plaque anatomy and function in carotids and in aortic aneurysms as well as inflammation and events. In coronary arteries, plaque assessment is still hampered by myocardium uptake but developments are being made. 18-FDG PET has been able to monitor inflammation before and after several therapies in animals and humans but to date the lack of standardization and the absence of prospective event-driven studies prevent this promising technique to be used in clinical practice.
18F-FDG PET 是一种用于炎症功能成像的新的非侵入性工具。低空间分辨率现在通过与 CT 或 MRI 的配准得到补偿。动物和组织学的新机制研究为解释通过缺氧、巨噬细胞浸润和分化获得的信号提供了新的见解。生物标志物研究的结果喜忧参半。最近有一些有趣的数据表明颈动脉和主动脉瘤中的斑块解剖结构和功能以及炎症和事件之间存在关联。在冠状动脉中，斑块评估仍然受到心肌摄取的影响，但正在取得进展。18F-FDG PET 已经能够在动物和人类中监测几种治疗前后的炎症，但到目前为止，缺乏标准化和前瞻性事件驱动的研究使得这项有前途的技术无法在临床实践中使用。
