Orchard G E, Shams M
Dermatopathology Department, St. John's Institute of Dermatology, St. Thomas' Hospital, London.
Br J Biomed Sci. 2012;69(2):56-61.
Dermatofibrosarcoma protuberans (DFSP) is a relatively uncommon tumour that arises in the dermis and underlying soft tissue. Surgical removal is the preferred treatment, with relatively wide clearance margins of 3 cm or more. Slow Mohs procedures are often employed successfully to treat patients with such tumours. Slow Mohs procedures offer the benefit of improved cure rates and maximal tissue conservation. However, dealing with such tissue successfully presents the laboratory with a host of technical problems. This report advocates a set protocol to follow for slow Mohs, based on the experience acquired from dealing with 37 cases of DFSP over a 12-year period. The report establishes the benefits of slow Mohs paraffin wax-embedded tissue over frozen sections in terms of improved morphology, tissue preservation and immunocytochemical labelling with anti-CD34.
隆突性皮肤纤维肉瘤（DFSP）是一种相对罕见的肿瘤，起源于真皮层及下方的软组织。手术切除是首选治疗方法，切除边缘相对较宽，需达3厘米或更宽。缓慢的莫氏手术常常成功用于治疗此类肿瘤患者。缓慢的莫氏手术具有提高治愈率和最大程度保留组织的优点。然而，成功处理此类组织给实验室带来了一系列技术问题。本报告基于12年间处理37例DFSP的经验，倡导一套用于缓慢莫氏手术的遵循方案。该报告确立了缓慢莫氏手术石蜡包埋组织相较于冰冻切片在改善形态、组织保存及抗CD34免疫细胞化学标记方面的优势。
