Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada.
J Microencapsul. 2012;29(8):729-38. doi: 10.3109/02652048.2011.651493. Epub 2012 Aug 8.
An extrusion-based encapsulation process has been developed for making salt grain-sized iron premix for salt fortification. The first step of extrusion agglomeration process has been studied and reported previously. The focus of this study is on the optimisation of the colour-masking and polymer coating steps. Several colour-masking techniques and polymer encapsulants were investigated at various encapsulation levels. Salt samples prepared by blending the resulting iron premixes with iodised salt retained more than 90% of the original iodine and more than 93% of the ferrous iron after 3 months storage at 35°C and 60% relative humidity (RH). Hydrophilic coatings such as hydroxypropyl methyl cellulose (HPMC) offered more protection at the 10% encapsulation level compared to other coating materials studied. All iron premix formulations exhibited high particle density, good bioavailability and acceptable organoleptic properties. The process using the most effective formulations and optimised operation parameters is ready for pilot scale testing and field studies.
已经开发出一种基于挤压的包封工艺，用于制造用于盐强化的盐粒状铁预混料。挤压团聚工艺的第一步已经在前一篇研究中进行了研究。本研究的重点是优化颜色掩蔽和聚合物涂层步骤。在不同的包封水平下研究了几种颜色掩蔽技术和聚合物包封剂。通过将所得铁预混料与碘化盐混合制备的盐样品在 35°C 和 60%相对湿度（RH）下储存 3 个月后，保留了原始碘的 90%以上和亚铁的 93%以上。与研究的其他涂层材料相比，亲水性涂层如羟丙基甲基纤维素（HPMC）在 10%包封水平下提供了更多的保护。所有铁预混料配方均表现出高颗粒密度、良好的生物利用度和可接受的感官特性。使用最有效配方和优化操作参数的工艺已准备好进行中试测试和现场研究。
