La Monaca Enza, Fodale Vincenzo
Department of Neuroscience, Psychiatric and Anesthesiological Sciences, University of Messina, Italy.
Curr Drug Saf. 2012 Apr;7(2):126-39. doi: 10.2174/157488612802715681.
Mitochondria are considered the powerhouses of the cell playing an important role in energy metabolism. However, they are highly vulnerable to inhibition or uncoupling of the energy harnessing process and run a high risk of causing catastrophic damage to the cell. Several anesthetics or drugs commonly given during anesthesia interact with mitochondria and affect their structure or impair respiratory chain functioning with decreased ATP production. Mitochondria, in fact, are a potential site of action of general and local anesthetics. The purpose of this review is to update present knowledge and describe the effects and molecular mechanisms of the action of the most used drugs of anesthesia on mitochondria.
线粒体被认为是细胞的动力源，在能量代谢中发挥着重要作用。然而，它们极易受到能量利用过程的抑制或解偶联影响，并且极有可能对细胞造成灾难性损伤。几种麻醉期间常用的麻醉剂或药物会与线粒体相互作用，影响其结构或损害呼吸链功能，导致ATP生成减少。事实上，线粒体是全身麻醉药和局部麻醉药的一个潜在作用位点。本综述的目的是更新现有知识，并描述最常用麻醉药物作用于线粒体的效应和分子机制。
