Aimé X, Charlet J, Furst F, Kuntz P, Trichet F, Dhombres F
ORPHANET, INSERM US24, France.
Stud Health Technol Inform. 2012;180:88-92.
In this paper, we introduce an application of Proxima and define a new measure of proximity between two concepts present in an ontology. The approach is based on the three dimensions of a conceptualization: intention with relations between concepts, expression with terms denoting concepts, and extension with instances of concepts. This preliminary work, in the field of rare diseases, involved the Orphanet Ontology of Rare Diseases (OntoOrpha) and corpus of texts extracted from Online Inheritance in Man (OMIM). The proximity measurements are consistent with an appropriate representation of groups of diseases in the ontology, which are derived from the Orphanet classifications of rare diseases. Other semantic relations are explored and new perspectives in medical knowledge curation are proposed.
在本文中，我们介绍了Proxima的一种应用，并定义了本体中两个概念之间接近度的一种新度量。该方法基于概念化的三个维度：概念之间具有关系的内涵、表示概念的术语的外延以及概念实例的扩展。这项在罕见病领域的初步工作涉及罕见病孤儿网络本体（OntoOrpha）和从《人类在线遗传》（OMIM）中提取的文本语料库。接近度测量与本体中疾病组的适当表示一致，这些疾病组源自罕见病的孤儿网络分类。还探索了其他语义关系，并提出了医学知识策展的新视角。
