沙利度胺治疗艾滋病患者中类固醇依赖的免疫重建炎症综合征。
Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS.
机构信息
Infectious Diseases Department, Montpellier University Hospital, Montpellier, France.
出版信息
AIDS. 2012 Oct 23;26(16):2110-2. doi: 10.1097/QAD.0b013e328358daea.
PMID:22874513
Abstract
Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined. We describe three HIV-infected patients with corticosteroid-dependent and life-threatening paradoxical immune reconstitution inflammatory syndrome for whom thalidomide treatment induced rapid clinical remission and permitted complete corticosteroid withdrawal without clinical relapse.
摘要
尽管皮质类固醇治疗，但复发或难治性免疫重建炎症综合征 (IRISs) 的管理尚未确定。我们描述了 3 例 HIV 感染患者，他们依赖皮质类固醇且发生危及生命的矛盾性免疫重建炎症综合征，沙利度胺治疗诱导了快速临床缓解，并允许完全停用皮质类固醇而无临床复发。
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