Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Med Sci Sports Exerc. 2012 Nov;44(11):2125-31. doi: 10.1249/MSS.0b013e3182640c4e.
The objective of this study is to prospectively examine the independent and joint effects of alcohol consumption and cardiorespiratory fitness on the incidence of metabolic syndrome (MetS) in a cohort of men.
A prospective examination was done of 3411 apparently healthy men at baseline, who came to the Cooper Clinic (Dallas, TX) for at least two preventive visits (1979-2010). Primary exposure variables were cardiorespiratory fitness and alcohol intake; the outcome measure was MetS and the components thereof. Cox proportional hazards models were computed to assess the relation between the exposure variables and the incidence of MetS while adjusting for confounders.
For a mean follow-up period of 9 yr (SD = 7.8), 276 men developed MetS. In multivariable analysis, a dose-response relationship was observed between increased levels of fitness and reduced MetS risk (moderate fitness: HR = 0.60; 95% confidence interval (CI), 0.43-0.82; high fitness: HR = 0.49, 95% CI, 0.35-0.69). When examining the independent effects of alcohol, light drinking increased the risk for MetS by 66% (HR = 1.66, 95% CI, 1.11-2.48). No statistically significant interaction effect was observed between alcohol and fitness in relation to MetS (P = 0.32). When assessing the relation between each exposure and the components of MetS, higher fitness consistently reduced the risk of all components, whereas lower alcohol intake reduced the risk of elevated glucose and blood pressure and increased the risk for low HDL cholesterol.
Among this cohort of men, higher fitness levels reduced the risk for MetS and its components. The relation between alcohol intake levels and metabolic risk was more complex and not reflected when examining MetS as a whole.
本研究旨在前瞻性地观察饮酒和心肺功能适应性对男性代谢综合征（MetS）发病率的独立和联合影响。
对 3411 名在基线时明显健康的男性进行前瞻性检查，他们因至少两次预防性就诊（1979-2010 年）来到库珀诊所（达拉斯，TX）。主要暴露变量是心肺功能适应性和酒精摄入量；结局测量指标是 MetS 及其组成部分。计算 Cox 比例风险模型来评估暴露变量与 MetS 发病率之间的关系，同时调整混杂因素。
平均随访 9 年（SD=7.8 年）期间，276 名男性发生 MetS。在多变量分析中，观察到随着适应能力的提高，MetS 风险呈剂量反应关系（中等适应能力：HR=0.60；95%置信区间[CI]，0.43-0.82；高适应能力：HR=0.49，95%CI，0.35-0.69）。当单独检查酒精的影响时，轻度饮酒使 MetS 的风险增加 66%（HR=1.66，95%CI，1.11-2.48）。在酒精和适应能力与 MetS 之间没有观察到统计学上显著的相互作用效应（P=0.32）。当评估每种暴露与 MetS 组成部分之间的关系时，更高的适应能力一致降低了所有组成部分的风险，而较低的酒精摄入量降低了血糖和血压升高的风险，并增加了低 HDL 胆固醇的风险。
在本队列男性中，更高的适应能力水平降低了 MetS 及其组成部分的风险。酒精摄入水平与代谢风险之间的关系更为复杂，当整体检查 MetS 时并不反映这种关系。
